Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer

This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgica...

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Autores principales: Shin, Hyeong Chan, Seo, Incheol, Jeong, Hasong, Byun, Sang Jun, Kim, Shin, Bae, Sung Uk, Kwon, Sun Young, Lee, Hye Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618174/
https://www.ncbi.nlm.nih.gov/pubmed/34833118
http://dx.doi.org/10.3390/life11111240
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author Shin, Hyeong Chan
Seo, Incheol
Jeong, Hasong
Byun, Sang Jun
Kim, Shin
Bae, Sung Uk
Kwon, Sun Young
Lee, Hye Won
author_facet Shin, Hyeong Chan
Seo, Incheol
Jeong, Hasong
Byun, Sang Jun
Kim, Shin
Bae, Sung Uk
Kwon, Sun Young
Lee, Hye Won
author_sort Shin, Hyeong Chan
collection PubMed
description This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.
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spelling pubmed-86181742021-11-27 Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer Shin, Hyeong Chan Seo, Incheol Jeong, Hasong Byun, Sang Jun Kim, Shin Bae, Sung Uk Kwon, Sun Young Lee, Hye Won Life (Basel) Article This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC. MDPI 2021-11-16 /pmc/articles/PMC8618174/ /pubmed/34833118 http://dx.doi.org/10.3390/life11111240 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shin, Hyeong Chan
Seo, Incheol
Jeong, Hasong
Byun, Sang Jun
Kim, Shin
Bae, Sung Uk
Kwon, Sun Young
Lee, Hye Won
Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_full Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_fullStr Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_full_unstemmed Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_short Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_sort prognostic impact of tumor-associated macrophages on long-term oncologic outcomes in colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618174/
https://www.ncbi.nlm.nih.gov/pubmed/34833118
http://dx.doi.org/10.3390/life11111240
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