Cargando…

Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol

Cannabidiol (CBD) has attracted increasing interest due to its therapeutic potential for treating numerous diseases. However, CBD is very lipophilic and has very unfavorable pharmacokinetics and low bioavailability. Efforts are focused on developing drug delivery systems for enhanced solubilization...

Descripción completa

Detalles Bibliográficos
Autores principales: Momekova, Denitsa, Danov, Yavor, Momekov, Georgi, Ivanov, Ervin, Petrov, Petar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618209/
https://www.ncbi.nlm.nih.gov/pubmed/34834189
http://dx.doi.org/10.3390/pharmaceutics13111774
_version_ 1784604692533215232
author Momekova, Denitsa
Danov, Yavor
Momekov, Georgi
Ivanov, Ervin
Petrov, Petar
author_facet Momekova, Denitsa
Danov, Yavor
Momekov, Georgi
Ivanov, Ervin
Petrov, Petar
author_sort Momekova, Denitsa
collection PubMed
description Cannabidiol (CBD) has attracted increasing interest due to its therapeutic potential for treating numerous diseases. However, CBD is very lipophilic and has very unfavorable pharmacokinetics and low bioavailability. Efforts are focused on developing drug delivery systems for enhanced solubilization and therapeutic activity of CBD. Here, we report the preparation of original super-macroporous cryogels from 2-hydroxyethyl cellulose (HEC) and β-cyclodextrin (β-CD) designed for the topical delivery of CBD. The cryogels were synthesized by photochemical crosslinking in a frozen aqueous system, purified, and then loaded with CBD. The effect of HEC/β-CD mass ratio (100:0; 50:50; 40:60 and 20:80) in the reaction mixture on the reaction efficiency, physico-mechanical properties of cryogels, drug release profile, and antineoplastic potential were evaluated in detail. The cryogels showed a bi-phasic release behavior: initial burst release in the first 3 hours followed by slower drug release which can be beneficial in the treatment of cutaneous neoplastic diseases.
format Online
Article
Text
id pubmed-8618209
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86182092021-11-27 Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol Momekova, Denitsa Danov, Yavor Momekov, Georgi Ivanov, Ervin Petrov, Petar Pharmaceutics Article Cannabidiol (CBD) has attracted increasing interest due to its therapeutic potential for treating numerous diseases. However, CBD is very lipophilic and has very unfavorable pharmacokinetics and low bioavailability. Efforts are focused on developing drug delivery systems for enhanced solubilization and therapeutic activity of CBD. Here, we report the preparation of original super-macroporous cryogels from 2-hydroxyethyl cellulose (HEC) and β-cyclodextrin (β-CD) designed for the topical delivery of CBD. The cryogels were synthesized by photochemical crosslinking in a frozen aqueous system, purified, and then loaded with CBD. The effect of HEC/β-CD mass ratio (100:0; 50:50; 40:60 and 20:80) in the reaction mixture on the reaction efficiency, physico-mechanical properties of cryogels, drug release profile, and antineoplastic potential were evaluated in detail. The cryogels showed a bi-phasic release behavior: initial burst release in the first 3 hours followed by slower drug release which can be beneficial in the treatment of cutaneous neoplastic diseases. MDPI 2021-10-23 /pmc/articles/PMC8618209/ /pubmed/34834189 http://dx.doi.org/10.3390/pharmaceutics13111774 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Momekova, Denitsa
Danov, Yavor
Momekov, Georgi
Ivanov, Ervin
Petrov, Petar
Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_full Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_fullStr Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_full_unstemmed Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_short Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
title_sort polysaccharide cryogels containing β-cyclodextrin for the delivery of cannabidiol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618209/
https://www.ncbi.nlm.nih.gov/pubmed/34834189
http://dx.doi.org/10.3390/pharmaceutics13111774
work_keys_str_mv AT momekovadenitsa polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol
AT danovyavor polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol
AT momekovgeorgi polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol
AT ivanovervin polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol
AT petrovpetar polysaccharidecryogelscontainingbcyclodextrinforthedeliveryofcannabidiol