Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin

Tetanus neurotoxin (TeNT) is a protein exotoxin produced by Clostridium tetani that causes the deadly spastic neuroparalysis of tetanus. It consists of a metalloprotease light chain and of a heavy chain linked via a disulphide bond. TeNT binds to the neuromuscular junction (NMJ) and it is retro-axon...

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Detalles Bibliográficos
Autores principales: Zanetti, Giulia, Mattarei, Andrea, Lista, Florigio, Rossetto, Ornella, Montecucco, Cesare, Pirazzini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618345/
https://www.ncbi.nlm.nih.gov/pubmed/34832916
http://dx.doi.org/10.3390/ph14111134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618345/
https://www.ncbi.nlm.nih.gov/pubmed/34832916
http://dx.doi.org/10.3390/ph14111134

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