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Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that suff...

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Autores principales: Mijanović, Olja, Pylaev, Timofey, Nikitkina, Angelina, Artyukhova, Margarita, Branković, Ana, Peshkova, Maria, Bikmulina, Polina, Turk, Boris, Bolevich, Sergey, Avetisov, Sergei, Timashev, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618371/
https://www.ncbi.nlm.nih.gov/pubmed/34832752
http://dx.doi.org/10.3390/mi12111336
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author Mijanović, Olja
Pylaev, Timofey
Nikitkina, Angelina
Artyukhova, Margarita
Branković, Ana
Peshkova, Maria
Bikmulina, Polina
Turk, Boris
Bolevich, Sergey
Avetisov, Sergei
Timashev, Peter
author_facet Mijanović, Olja
Pylaev, Timofey
Nikitkina, Angelina
Artyukhova, Margarita
Branković, Ana
Peshkova, Maria
Bikmulina, Polina
Turk, Boris
Bolevich, Sergey
Avetisov, Sergei
Timashev, Peter
author_sort Mijanović, Olja
collection PubMed
description Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant.
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spelling pubmed-86183712021-11-27 Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration Mijanović, Olja Pylaev, Timofey Nikitkina, Angelina Artyukhova, Margarita Branković, Ana Peshkova, Maria Bikmulina, Polina Turk, Boris Bolevich, Sergey Avetisov, Sergei Timashev, Peter Micromachines (Basel) Review Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant. MDPI 2021-10-30 /pmc/articles/PMC8618371/ /pubmed/34832752 http://dx.doi.org/10.3390/mi12111336 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mijanović, Olja
Pylaev, Timofey
Nikitkina, Angelina
Artyukhova, Margarita
Branković, Ana
Peshkova, Maria
Bikmulina, Polina
Turk, Boris
Bolevich, Sergey
Avetisov, Sergei
Timashev, Peter
Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_full Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_fullStr Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_full_unstemmed Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_short Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_sort tissue engineering meets nanotechnology: molecular mechanism modulations in cornea regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618371/
https://www.ncbi.nlm.nih.gov/pubmed/34832752
http://dx.doi.org/10.3390/mi12111336
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