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Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis

The first case of hyaline vascular type of unicentric Castleman disease (HV-UCD) was reported more than six decades ago. Since patients with HV-UCD are often asymptomatic and this condition is generally discovered incidentally on imaging tests, most of the previous reports were of mediastinal origin...

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Autores principales: Nishimura, Midori Filiz, Nishimura, Yoshito, Nishikori, Asami, Maekawa, Yukina, Maehama, Kanna, Yoshino, Tadashi, Sato, Yasuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618395/
https://www.ncbi.nlm.nih.gov/pubmed/34829355
http://dx.doi.org/10.3390/diagnostics11112008
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author Nishimura, Midori Filiz
Nishimura, Yoshito
Nishikori, Asami
Maekawa, Yukina
Maehama, Kanna
Yoshino, Tadashi
Sato, Yasuharu
author_facet Nishimura, Midori Filiz
Nishimura, Yoshito
Nishikori, Asami
Maekawa, Yukina
Maehama, Kanna
Yoshino, Tadashi
Sato, Yasuharu
author_sort Nishimura, Midori Filiz
collection PubMed
description The first case of hyaline vascular type of unicentric Castleman disease (HV-UCD) was reported more than six decades ago. Since patients with HV-UCD are often asymptomatic and this condition is generally discovered incidentally on imaging tests, most of the previous reports were of mediastinal origin detected by chest radiography. In recent years, improved access to imaging modalities has provided new insights in the diagnosis of this condition. In this study, we reviewed the detailed clinical and pathological findings of 38 HV-UCD cases (20 males and 18 females, mean age: 42.8 years). The most common site involved was the abdominal cavity (34.2%), followed by mediastinum (23.7%) and retroperitoneum (15.8%). In the abdominal cavity, mesenteric origin was the most common. The mean size of masses was 4.8 cm. Pathologically, thick hyalinized collagen fibers surrounding large blood vessels and calcification were observed (81.6% and 23.7%, respectively). Multinucleated giant cells resembling Warthin–Finkeldey cell were also observed in occasional cases (23.7%). This is a unique paper that summarizes detailed clinical and pathological findings of a large series of a rare disease. The clinical information presented in this paper is more plausible than previous views and is useful for accurate diagnosis and understanding of the disease.
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spelling pubmed-86183952021-11-27 Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis Nishimura, Midori Filiz Nishimura, Yoshito Nishikori, Asami Maekawa, Yukina Maehama, Kanna Yoshino, Tadashi Sato, Yasuharu Diagnostics (Basel) Article The first case of hyaline vascular type of unicentric Castleman disease (HV-UCD) was reported more than six decades ago. Since patients with HV-UCD are often asymptomatic and this condition is generally discovered incidentally on imaging tests, most of the previous reports were of mediastinal origin detected by chest radiography. In recent years, improved access to imaging modalities has provided new insights in the diagnosis of this condition. In this study, we reviewed the detailed clinical and pathological findings of 38 HV-UCD cases (20 males and 18 females, mean age: 42.8 years). The most common site involved was the abdominal cavity (34.2%), followed by mediastinum (23.7%) and retroperitoneum (15.8%). In the abdominal cavity, mesenteric origin was the most common. The mean size of masses was 4.8 cm. Pathologically, thick hyalinized collagen fibers surrounding large blood vessels and calcification were observed (81.6% and 23.7%, respectively). Multinucleated giant cells resembling Warthin–Finkeldey cell were also observed in occasional cases (23.7%). This is a unique paper that summarizes detailed clinical and pathological findings of a large series of a rare disease. The clinical information presented in this paper is more plausible than previous views and is useful for accurate diagnosis and understanding of the disease. MDPI 2021-10-28 /pmc/articles/PMC8618395/ /pubmed/34829355 http://dx.doi.org/10.3390/diagnostics11112008 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nishimura, Midori Filiz
Nishimura, Yoshito
Nishikori, Asami
Maekawa, Yukina
Maehama, Kanna
Yoshino, Tadashi
Sato, Yasuharu
Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_full Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_fullStr Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_full_unstemmed Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_short Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_sort clinical and pathological characteristics of hyaline-vascular type unicentric castleman disease: a 20-year retrospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618395/
https://www.ncbi.nlm.nih.gov/pubmed/34829355
http://dx.doi.org/10.3390/diagnostics11112008
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