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Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma

(1) Background: The incidence of papillary thyroid cancers is increasing. Papillary neoplasm metastasizes to the central and lateral lymph nodes of the neck. The recurrence rate is less than 30%. The gold standard of treatment for lymph node recurrences is surgery, but surgery is burdened by a high...

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Autores principales: Offi, Chiara, Misso, Claudia, Antonelli, Giovanni, Esposito, Maria Grazia, Brancaccio, Umberto, Spiezia, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618398/
https://www.ncbi.nlm.nih.gov/pubmed/34830577
http://dx.doi.org/10.3390/jcm10225295
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author Offi, Chiara
Misso, Claudia
Antonelli, Giovanni
Esposito, Maria Grazia
Brancaccio, Umberto
Spiezia, Stefano
author_facet Offi, Chiara
Misso, Claudia
Antonelli, Giovanni
Esposito, Maria Grazia
Brancaccio, Umberto
Spiezia, Stefano
author_sort Offi, Chiara
collection PubMed
description (1) Background: The incidence of papillary thyroid cancers is increasing. Papillary neoplasm metastasizes to the central and lateral lymph nodes of the neck. The recurrence rate is less than 30%. The gold standard of treatment for lymph node recurrences is surgery, but surgery is burdened by a high rate of complications. Therefore, laser ablation of recurrent lymph nodes has been recognized as an alternative treatment with minimal invasiveness, a low complication rate and a curative effect. (2) Methods: We analyzed 10 patients who underwent a total thyroidectomy and metabolic radiotherapy and who developed a lymph node recurrence in the laterocervical compartment in the following 12–18 months. (3) Results: Patients developed lymph node recurrence at IV and Vb levels in 70% and 30% of cases, respectively. All patients were treated with a single laser ablative session. Hydrodissection was performed in all patients. The energy delivered was 1120 ± 159.3 Joules and 3–4 Watts in 362 ± 45.7 s. No complications were reported. All patients underwent a 6-month follow-up. A volumetric reduction of 40.12 ± 2.2%, 49.1 ± 2.13% and 59.8 ± 3.05%, respectively at 1-, 3- and 6-months of follow-up was reported. (4) Conclusions: At 6 months, a fine needle aspiration was performed, which was negative for malignant cells and negative for a dosage of Thyroglobulin in eluate. The laser ablation is an effective alternative to surgical treatment.
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spelling pubmed-86183982021-11-27 Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma Offi, Chiara Misso, Claudia Antonelli, Giovanni Esposito, Maria Grazia Brancaccio, Umberto Spiezia, Stefano J Clin Med Article (1) Background: The incidence of papillary thyroid cancers is increasing. Papillary neoplasm metastasizes to the central and lateral lymph nodes of the neck. The recurrence rate is less than 30%. The gold standard of treatment for lymph node recurrences is surgery, but surgery is burdened by a high rate of complications. Therefore, laser ablation of recurrent lymph nodes has been recognized as an alternative treatment with minimal invasiveness, a low complication rate and a curative effect. (2) Methods: We analyzed 10 patients who underwent a total thyroidectomy and metabolic radiotherapy and who developed a lymph node recurrence in the laterocervical compartment in the following 12–18 months. (3) Results: Patients developed lymph node recurrence at IV and Vb levels in 70% and 30% of cases, respectively. All patients were treated with a single laser ablative session. Hydrodissection was performed in all patients. The energy delivered was 1120 ± 159.3 Joules and 3–4 Watts in 362 ± 45.7 s. No complications were reported. All patients underwent a 6-month follow-up. A volumetric reduction of 40.12 ± 2.2%, 49.1 ± 2.13% and 59.8 ± 3.05%, respectively at 1-, 3- and 6-months of follow-up was reported. (4) Conclusions: At 6 months, a fine needle aspiration was performed, which was negative for malignant cells and negative for a dosage of Thyroglobulin in eluate. The laser ablation is an effective alternative to surgical treatment. MDPI 2021-11-14 /pmc/articles/PMC8618398/ /pubmed/34830577 http://dx.doi.org/10.3390/jcm10225295 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Offi, Chiara
Misso, Claudia
Antonelli, Giovanni
Esposito, Maria Grazia
Brancaccio, Umberto
Spiezia, Stefano
Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma
title Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma
title_full Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma
title_fullStr Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma
title_full_unstemmed Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma
title_short Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma
title_sort laser ablation treatment of recurrent lymph node metastases from papillary thyroid carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618398/
https://www.ncbi.nlm.nih.gov/pubmed/34830577
http://dx.doi.org/10.3390/jcm10225295
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