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Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance

The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as a major concern both in public health and in food animal production systems. As a general classification, E. coli can be distinguished based on the ability to cause infection of the gastrointestinal system (IPEC)...

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Autores principales: Sora, Valerio M., Meroni, Gabriele, Martino, Piera A., Soggiu, Alessio, Bonizzi, Luigi, Zecconi, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618662/
https://www.ncbi.nlm.nih.gov/pubmed/34832511
http://dx.doi.org/10.3390/pathogens10111355
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author Sora, Valerio M.
Meroni, Gabriele
Martino, Piera A.
Soggiu, Alessio
Bonizzi, Luigi
Zecconi, Alfonso
author_facet Sora, Valerio M.
Meroni, Gabriele
Martino, Piera A.
Soggiu, Alessio
Bonizzi, Luigi
Zecconi, Alfonso
author_sort Sora, Valerio M.
collection PubMed
description The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as a major concern both in public health and in food animal production systems. As a general classification, E. coli can be distinguished based on the ability to cause infection of the gastrointestinal system (IPEC) or outside of it (ExPEC). Among the different pathogens, E. coli are becoming of great importance, and it has been suggested that ExPEC may harbor resistance genes that may be transferred to pathogenic or opportunistic bacteria. ExPEC strains are versatile bacteria that can cause urinary tract, bloodstream, prostate, and other infections at non-intestinal sites. In this context of rapidly increasing multidrug-resistance worldwide and a diminishingly effective antimicrobial arsenal to tackle resistant strains. ExPEC infections are now a serious public health threat worldwide. However, the clinical and economic impact of these infections and their optimal management are challenging, and consequently, there is an increasing awareness of the importance of ExPECs amongst healthcare professionals and the general public alike. This review aims to describe pathotype characteristics of ExPEC to increase our knowledge of these bacteria and, consequently, to increase our chances to control them and reduce the risk for AMR, following a One Health approach.
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spelling pubmed-86186622021-11-27 Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance Sora, Valerio M. Meroni, Gabriele Martino, Piera A. Soggiu, Alessio Bonizzi, Luigi Zecconi, Alfonso Pathogens Review The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as a major concern both in public health and in food animal production systems. As a general classification, E. coli can be distinguished based on the ability to cause infection of the gastrointestinal system (IPEC) or outside of it (ExPEC). Among the different pathogens, E. coli are becoming of great importance, and it has been suggested that ExPEC may harbor resistance genes that may be transferred to pathogenic or opportunistic bacteria. ExPEC strains are versatile bacteria that can cause urinary tract, bloodstream, prostate, and other infections at non-intestinal sites. In this context of rapidly increasing multidrug-resistance worldwide and a diminishingly effective antimicrobial arsenal to tackle resistant strains. ExPEC infections are now a serious public health threat worldwide. However, the clinical and economic impact of these infections and their optimal management are challenging, and consequently, there is an increasing awareness of the importance of ExPECs amongst healthcare professionals and the general public alike. This review aims to describe pathotype characteristics of ExPEC to increase our knowledge of these bacteria and, consequently, to increase our chances to control them and reduce the risk for AMR, following a One Health approach. MDPI 2021-10-20 /pmc/articles/PMC8618662/ /pubmed/34832511 http://dx.doi.org/10.3390/pathogens10111355 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sora, Valerio M.
Meroni, Gabriele
Martino, Piera A.
Soggiu, Alessio
Bonizzi, Luigi
Zecconi, Alfonso
Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance
title Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance
title_full Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance
title_fullStr Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance
title_full_unstemmed Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance
title_short Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance
title_sort extraintestinal pathogenic escherichia coli: virulence factors and antibiotic resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618662/
https://www.ncbi.nlm.nih.gov/pubmed/34832511
http://dx.doi.org/10.3390/pathogens10111355
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