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Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge
Genodermatoses represent a group of uncommon, hereditary, single-gene skin disorders, characterized by multisystem involvement, heterogeneous clinical manifestations and different degrees of morbidity and mortality. Some genodermatoses may have oral mucosa and nail involvement, since the oral cavity...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618664/ https://www.ncbi.nlm.nih.gov/pubmed/34830686 http://dx.doi.org/10.3390/jcm10225404 |
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author | Cantile, Tiziana Coppola, Noemi Caponio, Vito Carlo Alberto Russo, Daniela Bucci, Paolo Spagnuolo, Gianrico Mignogna, Michele Davide Leuci, Stefania |
author_facet | Cantile, Tiziana Coppola, Noemi Caponio, Vito Carlo Alberto Russo, Daniela Bucci, Paolo Spagnuolo, Gianrico Mignogna, Michele Davide Leuci, Stefania |
author_sort | Cantile, Tiziana |
collection | PubMed |
description | Genodermatoses represent a group of uncommon, hereditary, single-gene skin disorders, characterized by multisystem involvement, heterogeneous clinical manifestations and different degrees of morbidity and mortality. Some genodermatoses may have oral mucosa and nail involvement, since the oral cavity and cutaneous organ system, including nails, share a close embryologic origin. Nail disorders can manifest with nail hypoplasia or nail hypertrophy. Clinical pictures of affected oral mucosa can be extremely heterogeneous, ranging from asymptomatic papules to painful blisters, leukokeratosis, oral papillomas and fibromas to oral potentially malignant disorders and cancerous lesions. Oral mucosa and nails pathological features may occur synchronously or not and are usually associated with other systemic and skin manifestations. In some cases, oral mucosa and nails diseases may be distinct and constitute the principal sign of the genetic disorder, in other cases they represent only a part of the puzzle for the confirmation of the diagnosis. Continued awareness of the correlation between oral mucosa and nails findings can help physicians to diagnose genodermatosis in a timely manner, allowing more effective clinical management and prevention and/or early detection of complications. This article provides an overview of all specific genodermatoses affecting both oral mucosa and nails. Moreover, the correlation between teeth and nails is summarized in tabular form. |
format | Online Article Text |
id | pubmed-8618664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86186642021-11-27 Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge Cantile, Tiziana Coppola, Noemi Caponio, Vito Carlo Alberto Russo, Daniela Bucci, Paolo Spagnuolo, Gianrico Mignogna, Michele Davide Leuci, Stefania J Clin Med Review Genodermatoses represent a group of uncommon, hereditary, single-gene skin disorders, characterized by multisystem involvement, heterogeneous clinical manifestations and different degrees of morbidity and mortality. Some genodermatoses may have oral mucosa and nail involvement, since the oral cavity and cutaneous organ system, including nails, share a close embryologic origin. Nail disorders can manifest with nail hypoplasia or nail hypertrophy. Clinical pictures of affected oral mucosa can be extremely heterogeneous, ranging from asymptomatic papules to painful blisters, leukokeratosis, oral papillomas and fibromas to oral potentially malignant disorders and cancerous lesions. Oral mucosa and nails pathological features may occur synchronously or not and are usually associated with other systemic and skin manifestations. In some cases, oral mucosa and nails diseases may be distinct and constitute the principal sign of the genetic disorder, in other cases they represent only a part of the puzzle for the confirmation of the diagnosis. Continued awareness of the correlation between oral mucosa and nails findings can help physicians to diagnose genodermatosis in a timely manner, allowing more effective clinical management and prevention and/or early detection of complications. This article provides an overview of all specific genodermatoses affecting both oral mucosa and nails. Moreover, the correlation between teeth and nails is summarized in tabular form. MDPI 2021-11-19 /pmc/articles/PMC8618664/ /pubmed/34830686 http://dx.doi.org/10.3390/jcm10225404 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cantile, Tiziana Coppola, Noemi Caponio, Vito Carlo Alberto Russo, Daniela Bucci, Paolo Spagnuolo, Gianrico Mignogna, Michele Davide Leuci, Stefania Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge |
title | Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge |
title_full | Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge |
title_fullStr | Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge |
title_full_unstemmed | Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge |
title_short | Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge |
title_sort | oral mucosa and nails in genodermatoses: a diagnostic challenge |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618664/ https://www.ncbi.nlm.nih.gov/pubmed/34830686 http://dx.doi.org/10.3390/jcm10225404 |
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