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Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19

Deficiencies in smell and taste are common symptoms of COVID-19. Quantitative losses are well surveyed. This study focuses on qualitative changes such as phantosmia (hallucination of smell), parosmia (alteration of smell), and dysgeusia (alteration of taste) and possible connections with the adaptiv...

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Autores principales: Schambeck, Sophia E., Crowell, Claudia S., Wagner, Karolin I., D’Ippolito, Elvira, Burrell, Teresa, Mijočević, Hrvoje, Protzer, Ulrike, Busch, Dirk H., Gerhard, Markus, Poppert, Holger, Beyer, Henriette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618742/
https://www.ncbi.nlm.nih.gov/pubmed/34830550
http://dx.doi.org/10.3390/jcm10225266
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author Schambeck, Sophia E.
Crowell, Claudia S.
Wagner, Karolin I.
D’Ippolito, Elvira
Burrell, Teresa
Mijočević, Hrvoje
Protzer, Ulrike
Busch, Dirk H.
Gerhard, Markus
Poppert, Holger
Beyer, Henriette
author_facet Schambeck, Sophia E.
Crowell, Claudia S.
Wagner, Karolin I.
D’Ippolito, Elvira
Burrell, Teresa
Mijočević, Hrvoje
Protzer, Ulrike
Busch, Dirk H.
Gerhard, Markus
Poppert, Holger
Beyer, Henriette
author_sort Schambeck, Sophia E.
collection PubMed
description Deficiencies in smell and taste are common symptoms of COVID-19. Quantitative losses are well surveyed. This study focuses on qualitative changes such as phantosmia (hallucination of smell), parosmia (alteration of smell), and dysgeusia (alteration of taste) and possible connections with the adaptive immune system. Subjective experience of deficiency in taste and smell was assessed by two different questionnaires after a median of 100 and 244 days after first positive RT-PCR test. SARS-CoV-2-specific antibody levels were measured with the iFlash-SARS-CoV-2 assay. After 100 days a psychophysical screening test for olfactory and gustatory dysfunction was administered. 30 of 44 (68.2%) participants reported a chemosensory dysfunction (14 quantitative, 6 qualitative, 10 quantitative, and qualitative) during COVID-19, eleven (25.0%) participants (1 quantitative, 7 qualitative, 3 quantitative, and quantity) after 100 days, and 14 (31.8%) participants (1 quantitative, 10 qualitative, 3 quantitative and qualitative) after 244 days. Four (9.1%) participants, who were symptom-free after 100 days reported now recently arisen qualitative changes. Serological and T-cell analysis showed no correlation with impairment of taste and smell. In conclusion, qualitative changes can persist for several months and occur as late-onset symptoms months after full recovery from COVID-19-induced quantitative losses in taste and smell.
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spelling pubmed-86187422021-11-27 Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19 Schambeck, Sophia E. Crowell, Claudia S. Wagner, Karolin I. D’Ippolito, Elvira Burrell, Teresa Mijočević, Hrvoje Protzer, Ulrike Busch, Dirk H. Gerhard, Markus Poppert, Holger Beyer, Henriette J Clin Med Article Deficiencies in smell and taste are common symptoms of COVID-19. Quantitative losses are well surveyed. This study focuses on qualitative changes such as phantosmia (hallucination of smell), parosmia (alteration of smell), and dysgeusia (alteration of taste) and possible connections with the adaptive immune system. Subjective experience of deficiency in taste and smell was assessed by two different questionnaires after a median of 100 and 244 days after first positive RT-PCR test. SARS-CoV-2-specific antibody levels were measured with the iFlash-SARS-CoV-2 assay. After 100 days a psychophysical screening test for olfactory and gustatory dysfunction was administered. 30 of 44 (68.2%) participants reported a chemosensory dysfunction (14 quantitative, 6 qualitative, 10 quantitative, and qualitative) during COVID-19, eleven (25.0%) participants (1 quantitative, 7 qualitative, 3 quantitative, and quantity) after 100 days, and 14 (31.8%) participants (1 quantitative, 10 qualitative, 3 quantitative and qualitative) after 244 days. Four (9.1%) participants, who were symptom-free after 100 days reported now recently arisen qualitative changes. Serological and T-cell analysis showed no correlation with impairment of taste and smell. In conclusion, qualitative changes can persist for several months and occur as late-onset symptoms months after full recovery from COVID-19-induced quantitative losses in taste and smell. MDPI 2021-11-12 /pmc/articles/PMC8618742/ /pubmed/34830550 http://dx.doi.org/10.3390/jcm10225266 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schambeck, Sophia E.
Crowell, Claudia S.
Wagner, Karolin I.
D’Ippolito, Elvira
Burrell, Teresa
Mijočević, Hrvoje
Protzer, Ulrike
Busch, Dirk H.
Gerhard, Markus
Poppert, Holger
Beyer, Henriette
Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_full Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_fullStr Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_full_unstemmed Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_short Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_sort phantosmia, parosmia, and dysgeusia are prolonged and late-onset symptoms of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618742/
https://www.ncbi.nlm.nih.gov/pubmed/34830550
http://dx.doi.org/10.3390/jcm10225266
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