Cargando…

Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications

The biomedical field is currently reaping the benefits of research on biomimetic nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular materials for nature-inspired biomedical applications. These camouflage NPs are capable of retaining not only the physiochemical pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Naskar, Atanu, Cho, Hyejin, Lee, Sohee, Kim, Kwang-sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618801/
https://www.ncbi.nlm.nih.gov/pubmed/34834302
http://dx.doi.org/10.3390/pharmaceutics13111887
_version_ 1784604835295789056
author Naskar, Atanu
Cho, Hyejin
Lee, Sohee
Kim, Kwang-sun
author_facet Naskar, Atanu
Cho, Hyejin
Lee, Sohee
Kim, Kwang-sun
author_sort Naskar, Atanu
collection PubMed
description The biomedical field is currently reaping the benefits of research on biomimetic nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular materials for nature-inspired biomedical applications. These camouflage NPs are capable of retaining not only the physiochemical properties of synthetic nanoparticles but also the original biological functions of the cellular materials. Accordingly, NPs coated with cell-derived membrane components have achieved remarkable growth as prospective biomedical materials. Particularly, bacterial outer membrane vesicle (OMV), which is a cell membrane coating material for NPs, is regarded as an important molecule that can be employed in several biomedical applications, including immune response activation, cancer therapeutics, and treatment for bacterial infections with photothermal activity. The currently available cell membrane-coated NPs are summarized in this review. Furthermore, the general features of bacterial OMVs and several multifunctional NPs that could serve as inner core materials in the coating strategy are presented, and several methods that can be used to prepare OMV-coated NPs (OMV-NPs) and their characterization are highlighted. Finally, some perspectives of OMV-NPs in various biomedical applications for future potential breakthrough are discussed. This in-depth review, which includes potential challenges, will encourage researchers to fabricate innovative and improvised, new-generation biomimetic materials through future biomedical applications.
format Online
Article
Text
id pubmed-8618801
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86188012021-11-27 Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications Naskar, Atanu Cho, Hyejin Lee, Sohee Kim, Kwang-sun Pharmaceutics Review The biomedical field is currently reaping the benefits of research on biomimetic nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular materials for nature-inspired biomedical applications. These camouflage NPs are capable of retaining not only the physiochemical properties of synthetic nanoparticles but also the original biological functions of the cellular materials. Accordingly, NPs coated with cell-derived membrane components have achieved remarkable growth as prospective biomedical materials. Particularly, bacterial outer membrane vesicle (OMV), which is a cell membrane coating material for NPs, is regarded as an important molecule that can be employed in several biomedical applications, including immune response activation, cancer therapeutics, and treatment for bacterial infections with photothermal activity. The currently available cell membrane-coated NPs are summarized in this review. Furthermore, the general features of bacterial OMVs and several multifunctional NPs that could serve as inner core materials in the coating strategy are presented, and several methods that can be used to prepare OMV-coated NPs (OMV-NPs) and their characterization are highlighted. Finally, some perspectives of OMV-NPs in various biomedical applications for future potential breakthrough are discussed. This in-depth review, which includes potential challenges, will encourage researchers to fabricate innovative and improvised, new-generation biomimetic materials through future biomedical applications. MDPI 2021-11-07 /pmc/articles/PMC8618801/ /pubmed/34834302 http://dx.doi.org/10.3390/pharmaceutics13111887 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Naskar, Atanu
Cho, Hyejin
Lee, Sohee
Kim, Kwang-sun
Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_full Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_fullStr Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_full_unstemmed Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_short Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_sort biomimetic nanoparticles coated with bacterial outer membrane vesicles as a new-generation platform for biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618801/
https://www.ncbi.nlm.nih.gov/pubmed/34834302
http://dx.doi.org/10.3390/pharmaceutics13111887
work_keys_str_mv AT naskaratanu biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications
AT chohyejin biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications
AT leesohee biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications
AT kimkwangsun biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications