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Discovery of GOT1 Inhibitors from a Marine-Derived Aspergillus terreus That Act against Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating digestive system carcinoma with high incidence and death rates. PDAC cells are dependent on the Gln metabolism, which can preferentially utilize glutamic oxaloacetate transaminase 1 (GOT1) to maintain the redox homeostasis of cancer cells. The...

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Detalles Bibliográficos
Autores principales:	Yan, Shan, Qi, Changxing, Song, Wei, Xu, Qianqian, Gu, Lianghu, Sun, Weiguang, Zhang, Yonghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618880/ https://www.ncbi.nlm.nih.gov/pubmed/34822459 http://dx.doi.org/10.3390/md19110588

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