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Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months

Post-stroke depression (PSD) affects approximately one-third of stroke patients. PSD not only impairs recovery and lowers quality of life, but has also serious neurological consequences, high mortality, and stroke recurrence risks. Studies on PSD-related prognostic factors are still lacking, especia...

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Autores principales: Lee, Chan-Hyuk, Jeon, Su Hong, Kim, Min Ju, Ra, Gyu Dam, Lee, Yong-Hyun, Hong, Seung Hyeon, Shin, Byoung-Soo, Kang, Hyun Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618912/
https://www.ncbi.nlm.nih.gov/pubmed/34834530
http://dx.doi.org/10.3390/jpm11111178
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author Lee, Chan-Hyuk
Jeon, Su Hong
Kim, Min Ju
Ra, Gyu Dam
Lee, Yong-Hyun
Hong, Seung Hyeon
Shin, Byoung-Soo
Kang, Hyun Goo
author_facet Lee, Chan-Hyuk
Jeon, Su Hong
Kim, Min Ju
Ra, Gyu Dam
Lee, Yong-Hyun
Hong, Seung Hyeon
Shin, Byoung-Soo
Kang, Hyun Goo
author_sort Lee, Chan-Hyuk
collection PubMed
description Post-stroke depression (PSD) affects approximately one-third of stroke patients. PSD not only impairs recovery and lowers quality of life, but has also serious neurological consequences, high mortality, and stroke recurrence risks. Studies on PSD-related prognostic factors are still lacking, especially environmental factors. Moreover, relieving factors after PSD in stroke patients has not been reported. This study aimed to investigate (study design 1) risk factors for PSD diagnosis after three months, and (study design 2) related factors for the relieving of early PSD after three months. This retrospective study included 227 patients hospitalized for acute ischemic stroke within three days at Jeonbuk National University Hospital from January to December 2019. The depressive status was assessed using the Hamilton Depression Rating Scale (HDRS) at admission and after three months. Clinical and laboratory data were analyzed for relevant prognostic factors. (Study design 1) HDRS score at admission (adjusted odds ratio (aOR) 1.22, 95% confidence interval (CI) 1.14–1.31; p < 0.001) and hospitalization period (aOR 1.11, 95% CI 1.02–1.20; p = 0.013) were confirmed as prognostic factors of PSD after three months. (Study design 2) The National Institute of Health Stroke Scale (NIHSS) score at discharge (aOR 0.80, 95% CI 0.68–0.94; p = 0.006) and HDRS score at admission (aOR 0.80, 95% CI 0.71–0.89; p < 0.001) were confirmed as prognostic factors of depression improvement after three months. In conclusion, environmental factors such as hospitalization period could be important in managing PSD. Factors related to PSD improvement are expected to be helpful in establishing a strategy for PSD recovery.
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spelling pubmed-86189122021-11-27 Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months Lee, Chan-Hyuk Jeon, Su Hong Kim, Min Ju Ra, Gyu Dam Lee, Yong-Hyun Hong, Seung Hyeon Shin, Byoung-Soo Kang, Hyun Goo J Pers Med Article Post-stroke depression (PSD) affects approximately one-third of stroke patients. PSD not only impairs recovery and lowers quality of life, but has also serious neurological consequences, high mortality, and stroke recurrence risks. Studies on PSD-related prognostic factors are still lacking, especially environmental factors. Moreover, relieving factors after PSD in stroke patients has not been reported. This study aimed to investigate (study design 1) risk factors for PSD diagnosis after three months, and (study design 2) related factors for the relieving of early PSD after three months. This retrospective study included 227 patients hospitalized for acute ischemic stroke within three days at Jeonbuk National University Hospital from January to December 2019. The depressive status was assessed using the Hamilton Depression Rating Scale (HDRS) at admission and after three months. Clinical and laboratory data were analyzed for relevant prognostic factors. (Study design 1) HDRS score at admission (adjusted odds ratio (aOR) 1.22, 95% confidence interval (CI) 1.14–1.31; p < 0.001) and hospitalization period (aOR 1.11, 95% CI 1.02–1.20; p = 0.013) were confirmed as prognostic factors of PSD after three months. (Study design 2) The National Institute of Health Stroke Scale (NIHSS) score at discharge (aOR 0.80, 95% CI 0.68–0.94; p = 0.006) and HDRS score at admission (aOR 0.80, 95% CI 0.71–0.89; p < 0.001) were confirmed as prognostic factors of depression improvement after three months. In conclusion, environmental factors such as hospitalization period could be important in managing PSD. Factors related to PSD improvement are expected to be helpful in establishing a strategy for PSD recovery. MDPI 2021-11-11 /pmc/articles/PMC8618912/ /pubmed/34834530 http://dx.doi.org/10.3390/jpm11111178 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Chan-Hyuk
Jeon, Su Hong
Kim, Min Ju
Ra, Gyu Dam
Lee, Yong-Hyun
Hong, Seung Hyeon
Shin, Byoung-Soo
Kang, Hyun Goo
Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_full Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_fullStr Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_full_unstemmed Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_short Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_sort factors affecting post-stroke depression in acute ischemic stroke patients after 3 months
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618912/
https://www.ncbi.nlm.nih.gov/pubmed/34834530
http://dx.doi.org/10.3390/jpm11111178
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