Cargando…

Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections

Cardiotonic steroids are steroid-like natural compounds known to inhibit Na(+)/K(+)-ATPase pumps. To develop a broad-spectrum antiviral drug against the emerging coronavirus infection, this study assessed the antiviral properties of these compounds. The activity of seven types of cardiotonic steroid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Young-Hee, Jeon, Sangeun, Lee, Jihye, Kim, Seungtaek, Jang, Min Seong, Park, Chul Min, Song, Jong Hwan, Kim, Hyoung Rae, Kwon, Sunoh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618917/ https://www.ncbi.nlm.nih.gov/pubmed/34834252 http://dx.doi.org/10.3390/pharmaceutics13111839

Ejemplares similares

Natural Polyphenols, 1,2,3,4,6-O-Pentagalloyglucose and Proanthocyanidins, as Broad-Spectrum Anticoronaviral Inhibitors Targeting Mpro and RdRp of SARS-CoV-2
por: Jin, Young-Hee, et al.
Publicado: (2022)

Anticoronaviral Activity of the Natural Phloroglucinols, Dryocrassin ABBA and Filixic Acid ABA from the Rhizome of Dryopteris crassirhizoma by Targeting the Main Protease of SARS-CoV-2
por: Jin, Young-Hee, et al.
Publicado: (2022)

Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections
por: Jin, Young-Hee, et al.
Publicado: (2021)

Cardiotonic Steroids as Modulators of Neuroinflammation
por: Orellana, Ana Maria, et al.
Publicado: (2016)

Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors
por: Yoon, Ji Hye, et al.
Publicado: (2019)

Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors
por: Lee, Jun Young, et al.
Publicado: (2020)

Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2
por: Shin, Young Sup, et al.
Publicado: (2021)

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells
por: Kim, Dong Eon, et al.
Publicado: (2019)

Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads †
por: El-Seedi, Hesham R., et al.
Publicado: (2022)

Endogenous cardiotonic steroids and cardiovascular disease, where to next?
por: Pavlovic, Davor
Publicado: (2020)

Research Progress in Pharmacological Activities and Applications of Cardiotonic Steroids
por: Ren, Junwei, et al.
Publicado: (2022)

Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis
por: Agalakova, Natalia I., et al.
Publicado: (2021)

Probing the stereoselectivity of OleD-catalyzed glycosylation of cardiotonic steroids
por: Zhu, Xue-Lin, et al.
Publicado: (2018)

Antiviral activity against Middle East Respiratory Syndrome coronavirus by Montelukast, an anti-asthma drug
por: Gan, Hanjie Jonathan, et al.
Publicado: (2021)

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
por: Cavalcante-Silva, Luiz H. A., et al.
Publicado: (2017)

Na/K-ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids
por: Marck, Pauline V., et al.
Publicado: (2018)

Na(+),K(+)-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies
por: Markina, Alisa A., et al.
Publicado: (2023)

Conserved coronavirus proteins as targets of broad-spectrum antivirals
por: Melo-Filho, Cleber C., et al.
Publicado: (2022)

Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments
por: Lee, Jun Young, et al.
Publicado: (2021)

Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids
por: Tverskoi, Artem M., et al.
Publicado: (2021)

Corrigendum: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
por: Cavalcante-Silva, Luiz H. A., et al.
Publicado: (2018)

Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?
por: Orlov, Sergei N., et al.
Publicado: (2020)

Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
por: Jeon, Sangeun, et al.
Publicado: (2020)

Cardiotonic Steroids—A Possible Link Between High-Salt Diet and Organ Damage
por: Paczula, Aneta, et al.
Publicado: (2019)

Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats
por: Grigorova, Yulia N., et al.
Publicado: (2022)

Optimization of 2-Aminoquinazolin-4-(3H)-one Derivatives as Potent Inhibitors of SARS-CoV-2: Improved Synthesis and Pharmacokinetic Properties
por: Shin, Young Sup, et al.
Publicado: (2022)

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus
por: Chan, Jasper F.W., et al.
Publicado: (2013)

Broad-Spectrum Antivirals against Multiple Human and Animal Coronaviruses Infection
por: Saxena, Divyasha, et al.
Publicado: (2023)

Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
por: Han, Jinhe, et al.
Publicado: (2022)

Broad-Spectrum Antiviral Therapeutics
por: Rider, Todd H., et al.
Publicado: (2011)

Broad-spectrum antiviral agents
por: Zhu, Jun-Da, et al.
Publicado: (2015)

Broad-Spectrum Antivirals and Antiviral Drug Combinations
por: Oksenych, Valentyn, et al.
Publicado: (2022)

Structure-Activity Relationships of Several Cardiotonic Steroids with Respect to Inhibition of Ion Transport in Frog Muscle
por: Abeles, A. L.
Publicado: (1969)

Na(+)(i),K(+)(i)-Dependent and -Independent Signaling Triggered by Cardiotonic Steroids: Facts and Artifacts
por: Orlov, Sergei N., et al.
Publicado: (2017)

Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review
por: Słabiak-Błaż, Natalia, et al.
Publicado: (2021)

Ca(2+)-Driven Selectivity of the Effect of the Cardiotonic Steroid Marinobufagenin on Rabbit Sinoatrial Node Function
por: Segal, Sofia, et al.
Publicado: (2023)

Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update
por: Kainov, Denis, et al.
Publicado: (2022)

Modified cyclodextrins as broad-spectrum antivirals
por: Jones, Samuel T., et al.
Publicado: (2020)

Novel stereoselective bufadienolides reveal new insights into the requirements for Na(+), K(+)-ATPase inhibition by cardiotonic steroids
por: Tang, Hong-Jin, et al.
Publicado: (2016)

The Cardiotonic Steroid Marinobufagenin Is a Predictor of Increased Left Ventricular Mass in Obesity: The African-PREDICT Study
por: Strauss-Kruger, Michél, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_nnn21tpnbgq4a6l4stahs4jger