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Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improv...

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Autores principales: Hung, Yuan-Pin, Chen, Yu-Fon, Tsai, Pei-Jane, Huang, I-Hsiu, Ko, Wen-Chien, Jan, Jeng-Shiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618949/
https://www.ncbi.nlm.nih.gov/pubmed/34834328
http://dx.doi.org/10.3390/pharmaceutics13111913
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author Hung, Yuan-Pin
Chen, Yu-Fon
Tsai, Pei-Jane
Huang, I-Hsiu
Ko, Wen-Chien
Jan, Jeng-Shiung
author_facet Hung, Yuan-Pin
Chen, Yu-Fon
Tsai, Pei-Jane
Huang, I-Hsiu
Ko, Wen-Chien
Jan, Jeng-Shiung
author_sort Hung, Yuan-Pin
collection PubMed
description Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.
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spelling pubmed-86189492021-11-27 Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases Hung, Yuan-Pin Chen, Yu-Fon Tsai, Pei-Jane Huang, I-Hsiu Ko, Wen-Chien Jan, Jeng-Shiung Pharmaceutics Review Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future. MDPI 2021-11-12 /pmc/articles/PMC8618949/ /pubmed/34834328 http://dx.doi.org/10.3390/pharmaceutics13111913 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hung, Yuan-Pin
Chen, Yu-Fon
Tsai, Pei-Jane
Huang, I-Hsiu
Ko, Wen-Chien
Jan, Jeng-Shiung
Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
title Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
title_full Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
title_fullStr Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
title_full_unstemmed Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
title_short Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
title_sort advances in the application of nanomaterials as treatments for bacterial infectious diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618949/
https://www.ncbi.nlm.nih.gov/pubmed/34834328
http://dx.doi.org/10.3390/pharmaceutics13111913
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