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Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study

Deleted in malignant brain tumours 1 protein (DMBT1) and surfactant protein D (SFTPD) are antimicrobial peptides previously linked to inflammatory bowel disease (IBD) susceptibility. This study attempts to link the most potential IBD-associated polymorphisms in DMBT1 and SFTPD with the disease sever...

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Autores principales: Glapa-Nowak, Aleksandra, Szczepanik, Mariusz, Banaszkiewicz, Aleksandra, Iwańczak, Barbara, Kwiecień, Jarosław, Szaflarska-Popławska, Anna, Grzybowska-Chlebowczyk, Urszula, Osiecki, Marcin, Kierkuś, Jarosław, Banasiuk, Marcin, Banasiewicz, Tomasz, Madsen, Jens, Walkowiak, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618964/
https://www.ncbi.nlm.nih.gov/pubmed/34828659
http://dx.doi.org/10.3390/children8110946
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author Glapa-Nowak, Aleksandra
Szczepanik, Mariusz
Banaszkiewicz, Aleksandra
Iwańczak, Barbara
Kwiecień, Jarosław
Szaflarska-Popławska, Anna
Grzybowska-Chlebowczyk, Urszula
Osiecki, Marcin
Kierkuś, Jarosław
Banasiuk, Marcin
Banasiewicz, Tomasz
Madsen, Jens
Walkowiak, Jarosław
author_facet Glapa-Nowak, Aleksandra
Szczepanik, Mariusz
Banaszkiewicz, Aleksandra
Iwańczak, Barbara
Kwiecień, Jarosław
Szaflarska-Popławska, Anna
Grzybowska-Chlebowczyk, Urszula
Osiecki, Marcin
Kierkuś, Jarosław
Banasiuk, Marcin
Banasiewicz, Tomasz
Madsen, Jens
Walkowiak, Jarosław
author_sort Glapa-Nowak, Aleksandra
collection PubMed
description Deleted in malignant brain tumours 1 protein (DMBT1) and surfactant protein D (SFTPD) are antimicrobial peptides previously linked to inflammatory bowel disease (IBD) susceptibility. This study attempts to link the most potential IBD-associated polymorphisms in DMBT1 and SFTPD with the disease severity in children. A total of 406 IBD patients (Crohn’s disease (CD) n = 214 and ulcerative colitis (UC) n = 192) were genotyped using hydrolysis probe assay. Clinical expression was described by disease activity scales, albumin and C-reactive protein levels, localisation and behaviour (Paris classification), systemic steroid, immunosuppressive, biological, and surgical treatment, number of exacerbation-caused hospitalisations, relapses and nutritional status. IBD patients with the risk genotype (AA) in DMBT1 rs2981804 had more frequent biological treatment (AA: vs. AG/GG; p = 0.012), concomitant diseases (AA vs. AG vs. GG; p = 0.015) and cutaneous manifestations (AA vs. AG/GG, p = 0.008). In UC, rs2981804 genotypes might be linked with albumin concentrations at diagnosis (AA vs. AG vs. GG; p = 0.009). In CD, DMBT1 rs2981745 was significantly associated with the number of severe relapses per year of disease (p = 0.020) and time-to-immunosuppression (p = 0.045). SFTPD was seemingly found to be associated with age at first immunosuppression in IBD (CC vs. CT vs. TT; p = 0.048). In conclusion, selected polymorphisms of DMBT1 and SFTPD might be associated with some disease severity measures in children with IBD. However, the magnitude of associations and their clinical relevance might be minor.
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spelling pubmed-86189642021-11-27 Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study Glapa-Nowak, Aleksandra Szczepanik, Mariusz Banaszkiewicz, Aleksandra Iwańczak, Barbara Kwiecień, Jarosław Szaflarska-Popławska, Anna Grzybowska-Chlebowczyk, Urszula Osiecki, Marcin Kierkuś, Jarosław Banasiuk, Marcin Banasiewicz, Tomasz Madsen, Jens Walkowiak, Jarosław Children (Basel) Article Deleted in malignant brain tumours 1 protein (DMBT1) and surfactant protein D (SFTPD) are antimicrobial peptides previously linked to inflammatory bowel disease (IBD) susceptibility. This study attempts to link the most potential IBD-associated polymorphisms in DMBT1 and SFTPD with the disease severity in children. A total of 406 IBD patients (Crohn’s disease (CD) n = 214 and ulcerative colitis (UC) n = 192) were genotyped using hydrolysis probe assay. Clinical expression was described by disease activity scales, albumin and C-reactive protein levels, localisation and behaviour (Paris classification), systemic steroid, immunosuppressive, biological, and surgical treatment, number of exacerbation-caused hospitalisations, relapses and nutritional status. IBD patients with the risk genotype (AA) in DMBT1 rs2981804 had more frequent biological treatment (AA: vs. AG/GG; p = 0.012), concomitant diseases (AA vs. AG vs. GG; p = 0.015) and cutaneous manifestations (AA vs. AG/GG, p = 0.008). In UC, rs2981804 genotypes might be linked with albumin concentrations at diagnosis (AA vs. AG vs. GG; p = 0.009). In CD, DMBT1 rs2981745 was significantly associated with the number of severe relapses per year of disease (p = 0.020) and time-to-immunosuppression (p = 0.045). SFTPD was seemingly found to be associated with age at first immunosuppression in IBD (CC vs. CT vs. TT; p = 0.048). In conclusion, selected polymorphisms of DMBT1 and SFTPD might be associated with some disease severity measures in children with IBD. However, the magnitude of associations and their clinical relevance might be minor. MDPI 2021-10-21 /pmc/articles/PMC8618964/ /pubmed/34828659 http://dx.doi.org/10.3390/children8110946 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Glapa-Nowak, Aleksandra
Szczepanik, Mariusz
Banaszkiewicz, Aleksandra
Iwańczak, Barbara
Kwiecień, Jarosław
Szaflarska-Popławska, Anna
Grzybowska-Chlebowczyk, Urszula
Osiecki, Marcin
Kierkuś, Jarosław
Banasiuk, Marcin
Banasiewicz, Tomasz
Madsen, Jens
Walkowiak, Jarosław
Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_full Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_fullStr Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_full_unstemmed Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_short Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_sort genetic variants of dmbt1 and sftpd and disease severity in paediatric inflammatory bowel disease—a polish population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618964/
https://www.ncbi.nlm.nih.gov/pubmed/34828659
http://dx.doi.org/10.3390/children8110946
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