Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior

Serotonin (5-hydroxytryptamine, 5-HT) is a crucial signal in the neurogenic niche of the hippocampus, where it is involved in antidepressant action. Here, we utilized a new transgenic rat model (TetO-shTPH2), where brain 5-HT levels can be acutely altered based on doxycycline (Dox)-inducible shRNA-e...

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Detalles Bibliográficos
Autores principales: Sidorova, Maria, Kronenberg, Golo, Matthes, Susann, Petermann, Markus, Hellweg, Rainer, Tuchina, Oksana, Bader, Michael, Alenina, Natalia, Klempin, Friederike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618971/
https://www.ncbi.nlm.nih.gov/pubmed/34831469
http://dx.doi.org/10.3390/cells10113240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618971/
https://www.ncbi.nlm.nih.gov/pubmed/34831469
http://dx.doi.org/10.3390/cells10113240

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