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Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior

Serotonin (5-hydroxytryptamine, 5-HT) is a crucial signal in the neurogenic niche of the hippocampus, where it is involved in antidepressant action. Here, we utilized a new transgenic rat model (TetO-shTPH2), where brain 5-HT levels can be acutely altered based on doxycycline (Dox)-inducible shRNA-e...

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Detalles Bibliográficos
Autores principales:	Sidorova, Maria, Kronenberg, Golo, Matthes, Susann, Petermann, Markus, Hellweg, Rainer, Tuchina, Oksana, Bader, Michael, Alenina, Natalia, Klempin, Friederike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618971/ https://www.ncbi.nlm.nih.gov/pubmed/34831469 http://dx.doi.org/10.3390/cells10113240

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