In Vitro Ciliotoxicity and Cytotoxicity Testing of Repeated Chronic Exposure to Topical Nasal Formulations for Safety Studies

Certain active drugs and excipients of nasal formulations may impair ciliary function and mucociliary clearance. The ciliary beat frequency (CBF) is a key parameter for determining mucociliary clearance rate, and in vitro assessments of CBF have proven to be accurate and reproducible. Since topical...

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Detalles Bibliográficos
Autores principales: Tratnjek, Larisa, Sibinovska, Nadica, Kristan, Katja, Kreft, Mateja Erdani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618987/
https://www.ncbi.nlm.nih.gov/pubmed/34834166
http://dx.doi.org/10.3390/pharmaceutics13111750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618987/
https://www.ncbi.nlm.nih.gov/pubmed/34834166
http://dx.doi.org/10.3390/pharmaceutics13111750

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