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Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limit...

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Detalles Bibliográficos
Autores principales: Olăreț, Elena, Stancu, Izabela-Cristina, Iovu, Horia, Serafim, Andrada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619049/
https://www.ncbi.nlm.nih.gov/pubmed/34832165
http://dx.doi.org/10.3390/ma14226763
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author Olăreț, Elena
Stancu, Izabela-Cristina
Iovu, Horia
Serafim, Andrada
author_facet Olăreț, Elena
Stancu, Izabela-Cristina
Iovu, Horia
Serafim, Andrada
author_sort Olăreț, Elena
collection PubMed
description The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field.
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spelling pubmed-86190492021-11-27 Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications Olăreț, Elena Stancu, Izabela-Cristina Iovu, Horia Serafim, Andrada Materials (Basel) Review The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field. MDPI 2021-11-10 /pmc/articles/PMC8619049/ /pubmed/34832165 http://dx.doi.org/10.3390/ma14226763 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Olăreț, Elena
Stancu, Izabela-Cristina
Iovu, Horia
Serafim, Andrada
Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_full Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_fullStr Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_full_unstemmed Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_short Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_sort computed tomography as a characterization tool for engineered scaffolds with biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619049/
https://www.ncbi.nlm.nih.gov/pubmed/34832165
http://dx.doi.org/10.3390/ma14226763
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