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Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619049/ https://www.ncbi.nlm.nih.gov/pubmed/34832165 http://dx.doi.org/10.3390/ma14226763 |
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author | Olăreț, Elena Stancu, Izabela-Cristina Iovu, Horia Serafim, Andrada |
author_facet | Olăreț, Elena Stancu, Izabela-Cristina Iovu, Horia Serafim, Andrada |
author_sort | Olăreț, Elena |
collection | PubMed |
description | The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field. |
format | Online Article Text |
id | pubmed-8619049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86190492021-11-27 Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications Olăreț, Elena Stancu, Izabela-Cristina Iovu, Horia Serafim, Andrada Materials (Basel) Review The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field. MDPI 2021-11-10 /pmc/articles/PMC8619049/ /pubmed/34832165 http://dx.doi.org/10.3390/ma14226763 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Olăreț, Elena Stancu, Izabela-Cristina Iovu, Horia Serafim, Andrada Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications |
title | Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications |
title_full | Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications |
title_fullStr | Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications |
title_full_unstemmed | Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications |
title_short | Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications |
title_sort | computed tomography as a characterization tool for engineered scaffolds with biomedical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619049/ https://www.ncbi.nlm.nih.gov/pubmed/34832165 http://dx.doi.org/10.3390/ma14226763 |
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