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Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?

Background and Objectives: This study aimed to investigate whether predictive indicators for the deterioration of respiratory status can be derived from the deep learning data analysis of initial chest computed tomography (CT) scans of patients with coronavirus disease 2019 (COVID-19). Materials and...

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Autores principales: Takahashi, Marie, Fujioka, Tomoyuki, Horii, Toshihiro, Kimura, Koichiro, Kimura, Mizuki, Hashimoto, Yurika, Kitazume, Yoshio, Kishino, Mitsuhiro, Tateishi, Ukihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619125/
https://www.ncbi.nlm.nih.gov/pubmed/34833366
http://dx.doi.org/10.3390/medicina57111148
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author Takahashi, Marie
Fujioka, Tomoyuki
Horii, Toshihiro
Kimura, Koichiro
Kimura, Mizuki
Hashimoto, Yurika
Kitazume, Yoshio
Kishino, Mitsuhiro
Tateishi, Ukihide
author_facet Takahashi, Marie
Fujioka, Tomoyuki
Horii, Toshihiro
Kimura, Koichiro
Kimura, Mizuki
Hashimoto, Yurika
Kitazume, Yoshio
Kishino, Mitsuhiro
Tateishi, Ukihide
author_sort Takahashi, Marie
collection PubMed
description Background and Objectives: This study aimed to investigate whether predictive indicators for the deterioration of respiratory status can be derived from the deep learning data analysis of initial chest computed tomography (CT) scans of patients with coronavirus disease 2019 (COVID-19). Materials and Methods: Out of 117 CT scans of 75 patients with COVID-19 admitted to our hospital between April and June 2020, we retrospectively analyzed 79 CT scans that had a definite time of onset and were performed prior to any medication intervention. Patients were grouped according to the presence or absence of increased oxygen demand after CT scan. Quantitative volume data of lung opacity were measured automatically using a deep learning-based image analysis system. The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of the opacity volume data were calculated to evaluate the accuracy of the system in predicting the deterioration of respiratory status. Results: All 79 CT scans were included (median age, 62 years (interquartile range, 46–77 years); 56 (70.9%) were male. The volume of opacity was significantly higher for the increased oxygen demand group than for the nonincreased oxygen demand group (585.3 vs. 132.8 mL, p < 0.001). The sensitivity, specificity, and AUC were 76.5%, 68.2%, and 0.737, respectively, in the prediction of increased oxygen demand. Conclusion: Deep learning-based quantitative analysis of the affected lung volume in the initial CT scans of patients with COVID-19 can predict the deterioration of respiratory status to improve treatment and resource management.
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spelling pubmed-86191252021-11-27 Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia? Takahashi, Marie Fujioka, Tomoyuki Horii, Toshihiro Kimura, Koichiro Kimura, Mizuki Hashimoto, Yurika Kitazume, Yoshio Kishino, Mitsuhiro Tateishi, Ukihide Medicina (Kaunas) Article Background and Objectives: This study aimed to investigate whether predictive indicators for the deterioration of respiratory status can be derived from the deep learning data analysis of initial chest computed tomography (CT) scans of patients with coronavirus disease 2019 (COVID-19). Materials and Methods: Out of 117 CT scans of 75 patients with COVID-19 admitted to our hospital between April and June 2020, we retrospectively analyzed 79 CT scans that had a definite time of onset and were performed prior to any medication intervention. Patients were grouped according to the presence or absence of increased oxygen demand after CT scan. Quantitative volume data of lung opacity were measured automatically using a deep learning-based image analysis system. The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of the opacity volume data were calculated to evaluate the accuracy of the system in predicting the deterioration of respiratory status. Results: All 79 CT scans were included (median age, 62 years (interquartile range, 46–77 years); 56 (70.9%) were male. The volume of opacity was significantly higher for the increased oxygen demand group than for the nonincreased oxygen demand group (585.3 vs. 132.8 mL, p < 0.001). The sensitivity, specificity, and AUC were 76.5%, 68.2%, and 0.737, respectively, in the prediction of increased oxygen demand. Conclusion: Deep learning-based quantitative analysis of the affected lung volume in the initial CT scans of patients with COVID-19 can predict the deterioration of respiratory status to improve treatment and resource management. MDPI 2021-10-22 /pmc/articles/PMC8619125/ /pubmed/34833366 http://dx.doi.org/10.3390/medicina57111148 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takahashi, Marie
Fujioka, Tomoyuki
Horii, Toshihiro
Kimura, Koichiro
Kimura, Mizuki
Hashimoto, Yurika
Kitazume, Yoshio
Kishino, Mitsuhiro
Tateishi, Ukihide
Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?
title Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?
title_full Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?
title_fullStr Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?
title_full_unstemmed Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?
title_short Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?
title_sort can deep learning-based volumetric analysis predict oxygen demand increase in patients with covid-19 pneumonia?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619125/
https://www.ncbi.nlm.nih.gov/pubmed/34833366
http://dx.doi.org/10.3390/medicina57111148
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