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Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C

Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At b...

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Autores principales: Gheorghe, Dorin Nicolae, Popescu, Dora Maria, Salan, Alex, Boldeanu, Mihail Virgil, Ionele, Claudiu Marinel, Pitru, Allma, Turcu-Stiolica, Adina, Camen, Adrian, Florescu, Cristina, Rogoveanu, Ion, Surlin, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619210/
https://www.ncbi.nlm.nih.gov/pubmed/34830557
http://dx.doi.org/10.3390/jcm10225275
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author Gheorghe, Dorin Nicolae
Popescu, Dora Maria
Salan, Alex
Boldeanu, Mihail Virgil
Ionele, Claudiu Marinel
Pitru, Allma
Turcu-Stiolica, Adina
Camen, Adrian
Florescu, Cristina
Rogoveanu, Ion
Surlin, Petra
author_facet Gheorghe, Dorin Nicolae
Popescu, Dora Maria
Salan, Alex
Boldeanu, Mihail Virgil
Ionele, Claudiu Marinel
Pitru, Allma
Turcu-Stiolica, Adina
Camen, Adrian
Florescu, Cristina
Rogoveanu, Ion
Surlin, Petra
author_sort Gheorghe, Dorin Nicolae
collection PubMed
description Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At baseline, selected patients were clinically evaluated for their periodontal status. A subsequent quantitative assessment of C-reactive protein and pentraxin-3 in samples of gingival fluid was performed by Enzyme-Linked Immunosorbent Assay (ELISA). Afterwards, NSPT was performed. Three months after NSPT, the clinical and ELISA assessments were repeated. The results show an improvement of the clinical parameters in periodontitis patients at the three-month recall. In chronic hepatitis C patients with periodontitis, the gingival fluid levels of pro-inflammatory markers reduced significantly. The targeted markers also expressed significant correlations with the clinical parameters used for the assessment of periodontitis’ severity. The results suggest that, while chronic hepatitis C patients exhibited a more negative periodontal status at baseline as compared to non-hepatitis ones, NSPT is effective in decreasing the local periodontal inflammatory reaction and in proving the periodontal status of this type of patients. Given the limitation of the study, periodontal screening and NSPT should be included in the integrated therapeutical approach of chronic hepatitis C patients, for its impact on the local inflammatory response.
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spelling pubmed-86192102021-11-27 Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C Gheorghe, Dorin Nicolae Popescu, Dora Maria Salan, Alex Boldeanu, Mihail Virgil Ionele, Claudiu Marinel Pitru, Allma Turcu-Stiolica, Adina Camen, Adrian Florescu, Cristina Rogoveanu, Ion Surlin, Petra J Clin Med Article Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At baseline, selected patients were clinically evaluated for their periodontal status. A subsequent quantitative assessment of C-reactive protein and pentraxin-3 in samples of gingival fluid was performed by Enzyme-Linked Immunosorbent Assay (ELISA). Afterwards, NSPT was performed. Three months after NSPT, the clinical and ELISA assessments were repeated. The results show an improvement of the clinical parameters in periodontitis patients at the three-month recall. In chronic hepatitis C patients with periodontitis, the gingival fluid levels of pro-inflammatory markers reduced significantly. The targeted markers also expressed significant correlations with the clinical parameters used for the assessment of periodontitis’ severity. The results suggest that, while chronic hepatitis C patients exhibited a more negative periodontal status at baseline as compared to non-hepatitis ones, NSPT is effective in decreasing the local periodontal inflammatory reaction and in proving the periodontal status of this type of patients. Given the limitation of the study, periodontal screening and NSPT should be included in the integrated therapeutical approach of chronic hepatitis C patients, for its impact on the local inflammatory response. MDPI 2021-11-13 /pmc/articles/PMC8619210/ /pubmed/34830557 http://dx.doi.org/10.3390/jcm10225275 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gheorghe, Dorin Nicolae
Popescu, Dora Maria
Salan, Alex
Boldeanu, Mihail Virgil
Ionele, Claudiu Marinel
Pitru, Allma
Turcu-Stiolica, Adina
Camen, Adrian
Florescu, Cristina
Rogoveanu, Ion
Surlin, Petra
Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_full Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_fullStr Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_full_unstemmed Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_short Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_sort non-surgical periodontal therapy could improve the periodontal inflammatory status in patients with periodontitis and chronic hepatitis c
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619210/
https://www.ncbi.nlm.nih.gov/pubmed/34830557
http://dx.doi.org/10.3390/jcm10225275
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