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Chronic Pancreatitis: The True Pathogenic Culprit within the SPINK1 N34S-Containing Haplotype Is No Longer at Large

A diverse range of loss-of-function variants in the SPINK1 gene (encoding pancreatic secretory trypsin inhibitor) has been identified in patients with chronic pancreatitis (CP). The haplotype harboring the SPINK1 c.101A>G (p.Asn34Ser or N34S) variant (rs17107315:T>C) is one of the most importa...

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Detalles Bibliográficos
Autores principales:	Pu, Na, Masson, Emmanuelle, Cooper, David N., Génin, Emmanuelle, Férec, Claude, Chen, Jian-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Opinion
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619230/ https://www.ncbi.nlm.nih.gov/pubmed/34828289 http://dx.doi.org/10.3390/genes12111683

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