L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation

Aims: Tay–Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that cause progressive neurodegeneration in infants and young children. Impaired hydrolysis catalysed by β-hexosaminidase A (HexA) leads to the accumulation of GM2 ganglioside in neuron...

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Detalles Bibliográficos
Autores principales: Castejón-Vega, Beatriz, Rubio, Alejandro, Pérez-Pulido, Antonio J., Quiles, José L., Lane, Jon D., Fernández-Domínguez, Beatriz, Cachón-González, María Begoña, Martín-Ruiz, Carmen, Sanz, Alberto, Cox, Timothy M., Alcocer-Gómez, Elísabet, Cordero, Mario D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619250/
https://www.ncbi.nlm.nih.gov/pubmed/34831346
http://dx.doi.org/10.3390/cells10113122

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