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Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes

A synthetic material of silicone rubber was used to construct an artificial lens capsule (ALC) in order to replicate the biomechanical behaviour of human lens capsule. The silicone rubber was characterised by monotonic and cyclic mechanical tests to reveal its hyper-elastic behaviour under uniaxial...

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Autores principales: Wei, Huidong, Wolffsohn, James S., Gomes de Oliveira, Otavio, Davies, Leon N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619262/
https://www.ncbi.nlm.nih.gov/pubmed/34833214
http://dx.doi.org/10.3390/polym13223916
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author Wei, Huidong
Wolffsohn, James S.
Gomes de Oliveira, Otavio
Davies, Leon N.
author_facet Wei, Huidong
Wolffsohn, James S.
Gomes de Oliveira, Otavio
Davies, Leon N.
author_sort Wei, Huidong
collection PubMed
description A synthetic material of silicone rubber was used to construct an artificial lens capsule (ALC) in order to replicate the biomechanical behaviour of human lens capsule. The silicone rubber was characterised by monotonic and cyclic mechanical tests to reveal its hyper-elastic behaviour under uniaxial tension and simple shear as well as the rate independence. A hyper-elastic constitutive model was calibrated by the testing data and incorporated into finite element analysis (FEA). An experimental setup to simulate eye focusing (accommodation) of ALC was performed to validate the FEA model by evaluating the shape change and reaction force. The characterisation and modelling approach provided an insight into the intrinsic behaviour of materials, addressing the inflating pressure and effective stretch of ALC under the focusing process. The proposed methodology offers a virtual testing environment mimicking human capsules for the variability of dimension and stiffness, which will facilitate the verification of new ophthalmic prototype such as accommodating intraocular lenses (AIOLs).
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spelling pubmed-86192622021-11-27 Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes Wei, Huidong Wolffsohn, James S. Gomes de Oliveira, Otavio Davies, Leon N. Polymers (Basel) Article A synthetic material of silicone rubber was used to construct an artificial lens capsule (ALC) in order to replicate the biomechanical behaviour of human lens capsule. The silicone rubber was characterised by monotonic and cyclic mechanical tests to reveal its hyper-elastic behaviour under uniaxial tension and simple shear as well as the rate independence. A hyper-elastic constitutive model was calibrated by the testing data and incorporated into finite element analysis (FEA). An experimental setup to simulate eye focusing (accommodation) of ALC was performed to validate the FEA model by evaluating the shape change and reaction force. The characterisation and modelling approach provided an insight into the intrinsic behaviour of materials, addressing the inflating pressure and effective stretch of ALC under the focusing process. The proposed methodology offers a virtual testing environment mimicking human capsules for the variability of dimension and stiffness, which will facilitate the verification of new ophthalmic prototype such as accommodating intraocular lenses (AIOLs). MDPI 2021-11-12 /pmc/articles/PMC8619262/ /pubmed/34833214 http://dx.doi.org/10.3390/polym13223916 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wei, Huidong
Wolffsohn, James S.
Gomes de Oliveira, Otavio
Davies, Leon N.
Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes
title Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes
title_full Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes
title_fullStr Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes
title_full_unstemmed Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes
title_short Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes
title_sort characterisation and modelling of an artificial lens capsule mimicking accommodation of human eyes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619262/
https://www.ncbi.nlm.nih.gov/pubmed/34833214
http://dx.doi.org/10.3390/polym13223916
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