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Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics Lactobacillus plantarum PS128 as an intervention to examine if pr...

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Autores principales: Wu, Chang-Chun, Wong, Lee-Chin, Hsu, Chia-Jui, Yang, Chianne-Wen, Tsai, Ying-Chieh, Cheng, Feng-Shiang, Hu, Hsiao-Yun, Lee, Wang-Tso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619307/
https://www.ncbi.nlm.nih.gov/pubmed/34835954
http://dx.doi.org/10.3390/nu13113698
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author Wu, Chang-Chun
Wong, Lee-Chin
Hsu, Chia-Jui
Yang, Chianne-Wen
Tsai, Ying-Chieh
Cheng, Feng-Shiang
Hu, Hsiao-Yun
Lee, Wang-Tso
author_facet Wu, Chang-Chun
Wong, Lee-Chin
Hsu, Chia-Jui
Yang, Chianne-Wen
Tsai, Ying-Chieh
Cheng, Feng-Shiang
Hu, Hsiao-Yun
Lee, Wang-Tso
author_sort Wu, Chang-Chun
collection PubMed
description Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics Lactobacillus plantarum PS128 as an intervention to examine if probiotics improve symptoms of children with Tourette syndrome. This study enrolled children aged 5 to 18 years old who fulfilled DSM-V diagnostic criteria for Tourette syndrome. Patients were assessed before initiating the trial, at one month, and at two months after randomization. The primary outcome was evaluated by Yale Global Tic Severity Scale (YGTSS), and the secondary outcome studied the possible comorbidities in these children. The results revealed no significant difference in improvement in YGTSS between the control group and the PS128 group. As for secondary endpoints, an analysis of Conners’ Continuous Performance Test (CPT) showed improvement in commission and detectability in the PS128 group. In conclusion, although probiotics may not have tic-reducing effects in children with Tourette syndrome, it may have benefits on comorbidities such as attention deficit and hyperactivity disorder (ADHD). Further studies are needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.
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spelling pubmed-86193072021-11-27 Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome Wu, Chang-Chun Wong, Lee-Chin Hsu, Chia-Jui Yang, Chianne-Wen Tsai, Ying-Chieh Cheng, Feng-Shiang Hu, Hsiao-Yun Lee, Wang-Tso Nutrients Article Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics Lactobacillus plantarum PS128 as an intervention to examine if probiotics improve symptoms of children with Tourette syndrome. This study enrolled children aged 5 to 18 years old who fulfilled DSM-V diagnostic criteria for Tourette syndrome. Patients were assessed before initiating the trial, at one month, and at two months after randomization. The primary outcome was evaluated by Yale Global Tic Severity Scale (YGTSS), and the secondary outcome studied the possible comorbidities in these children. The results revealed no significant difference in improvement in YGTSS between the control group and the PS128 group. As for secondary endpoints, an analysis of Conners’ Continuous Performance Test (CPT) showed improvement in commission and detectability in the PS128 group. In conclusion, although probiotics may not have tic-reducing effects in children with Tourette syndrome, it may have benefits on comorbidities such as attention deficit and hyperactivity disorder (ADHD). Further studies are needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children. MDPI 2021-10-21 /pmc/articles/PMC8619307/ /pubmed/34835954 http://dx.doi.org/10.3390/nu13113698 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Chang-Chun
Wong, Lee-Chin
Hsu, Chia-Jui
Yang, Chianne-Wen
Tsai, Ying-Chieh
Cheng, Feng-Shiang
Hu, Hsiao-Yun
Lee, Wang-Tso
Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_full Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_fullStr Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_full_unstemmed Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_short Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_sort randomized controlled trial of probiotic ps128 in children with tourette syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619307/
https://www.ncbi.nlm.nih.gov/pubmed/34835954
http://dx.doi.org/10.3390/nu13113698
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