The Role of Chemokines in Cervical Cancers

Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. T...

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Detalles Bibliográficos
Autores principales: Garrido, Fabian, Wild, Carl Mathis, Mittelberger, Johanna, Dobler, Franziska, Schneider, Mariella, Ansorge, Nadine, Köpke, Melitta, Strieder, Annamarie, Ditsch, Nina, Jeschke, Udo, Dannecker, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619382/
https://www.ncbi.nlm.nih.gov/pubmed/34833360
http://dx.doi.org/10.3390/medicina57111141
Descripción
Sumario:Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.

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