The Role of Chemokines in Cervical Cancers

Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. T...

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Autores principales: Garrido, Fabian, Wild, Carl Mathis, Mittelberger, Johanna, Dobler, Franziska, Schneider, Mariella, Ansorge, Nadine, Köpke, Melitta, Strieder, Annamarie, Ditsch, Nina, Jeschke, Udo, Dannecker, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619382/
https://www.ncbi.nlm.nih.gov/pubmed/34833360
http://dx.doi.org/10.3390/medicina57111141
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author Garrido, Fabian
Wild, Carl Mathis
Mittelberger, Johanna
Dobler, Franziska
Schneider, Mariella
Ansorge, Nadine
Köpke, Melitta
Strieder, Annamarie
Ditsch, Nina
Jeschke, Udo
Dannecker, Christian
author_facet Garrido, Fabian
Wild, Carl Mathis
Mittelberger, Johanna
Dobler, Franziska
Schneider, Mariella
Ansorge, Nadine
Köpke, Melitta
Strieder, Annamarie
Ditsch, Nina
Jeschke, Udo
Dannecker, Christian
author_sort Garrido, Fabian
collection PubMed
description Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.
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spelling pubmed-86193822021-11-27 The Role of Chemokines in Cervical Cancers Garrido, Fabian Wild, Carl Mathis Mittelberger, Johanna Dobler, Franziska Schneider, Mariella Ansorge, Nadine Köpke, Melitta Strieder, Annamarie Ditsch, Nina Jeschke, Udo Dannecker, Christian Medicina (Kaunas) Review Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research. MDPI 2021-10-21 /pmc/articles/PMC8619382/ /pubmed/34833360 http://dx.doi.org/10.3390/medicina57111141 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garrido, Fabian
Wild, Carl Mathis
Mittelberger, Johanna
Dobler, Franziska
Schneider, Mariella
Ansorge, Nadine
Köpke, Melitta
Strieder, Annamarie
Ditsch, Nina
Jeschke, Udo
Dannecker, Christian
The Role of Chemokines in Cervical Cancers
title The Role of Chemokines in Cervical Cancers
title_full The Role of Chemokines in Cervical Cancers
title_fullStr The Role of Chemokines in Cervical Cancers
title_full_unstemmed The Role of Chemokines in Cervical Cancers
title_short The Role of Chemokines in Cervical Cancers
title_sort role of chemokines in cervical cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619382/
https://www.ncbi.nlm.nih.gov/pubmed/34833360
http://dx.doi.org/10.3390/medicina57111141
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