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Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men
Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619397/ https://www.ncbi.nlm.nih.gov/pubmed/34833152 http://dx.doi.org/10.3390/life11111276 |
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author | Sahlin, K. Barbara Pla, Indira de Siqueira Guedes, Jéssica Pawłowski, Krzysztof Appelqvist, Roger Marko-Varga, György Domont, Gilberto Barbosa César Sousa Nogueira, Fábio Giwercman, Aleksander Sanchez, Aniel Malm, Johan |
author_facet | Sahlin, K. Barbara Pla, Indira de Siqueira Guedes, Jéssica Pawłowski, Krzysztof Appelqvist, Roger Marko-Varga, György Domont, Gilberto Barbosa César Sousa Nogueira, Fábio Giwercman, Aleksander Sanchez, Aniel Malm, Johan |
author_sort | Sahlin, K. Barbara |
collection | PubMed |
description | Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations. |
format | Online Article Text |
id | pubmed-8619397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86193972021-11-27 Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men Sahlin, K. Barbara Pla, Indira de Siqueira Guedes, Jéssica Pawłowski, Krzysztof Appelqvist, Roger Marko-Varga, György Domont, Gilberto Barbosa César Sousa Nogueira, Fábio Giwercman, Aleksander Sanchez, Aniel Malm, Johan Life (Basel) Article Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations. MDPI 2021-11-22 /pmc/articles/PMC8619397/ /pubmed/34833152 http://dx.doi.org/10.3390/life11111276 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sahlin, K. Barbara Pla, Indira de Siqueira Guedes, Jéssica Pawłowski, Krzysztof Appelqvist, Roger Marko-Varga, György Domont, Gilberto Barbosa César Sousa Nogueira, Fábio Giwercman, Aleksander Sanchez, Aniel Malm, Johan Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men |
title | Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men |
title_full | Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men |
title_fullStr | Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men |
title_full_unstemmed | Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men |
title_short | Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men |
title_sort | short-term effect of induced alterations in testosterone levels on fasting plasma amino acid levels in healthy young men |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619397/ https://www.ncbi.nlm.nih.gov/pubmed/34833152 http://dx.doi.org/10.3390/life11111276 |
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