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Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase
The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protecte...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619453/ https://www.ncbi.nlm.nih.gov/pubmed/34832964 http://dx.doi.org/10.3390/ph14111182 |
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author | Vimberg, Vladimir Zieglerova, Leona Mazumdar, Aninda Szűcs, Zsolt Borbás, Aniko Herczegh, Pál Novotna, Gabriela Balikova |
author_facet | Vimberg, Vladimir Zieglerova, Leona Mazumdar, Aninda Szűcs, Zsolt Borbás, Aniko Herczegh, Pál Novotna, Gabriela Balikova |
author_sort | Vimberg, Vladimir |
collection | PubMed |
description | The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protected in a biofilm environment. In this paper, we compare the in vitro activities of two new semisynthetic glycopeptide antibiotics, MA79 and ERJ390, with two clinically used glycopeptide antibiotics—vancomycin and teicoplanin. The new antibiotics effectively killed not only exponentially growing cells of Staphylococcus aureus, but also cells in the stationary growth phase and biofilm. |
format | Online Article Text |
id | pubmed-8619453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86194532021-11-27 Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase Vimberg, Vladimir Zieglerova, Leona Mazumdar, Aninda Szűcs, Zsolt Borbás, Aniko Herczegh, Pál Novotna, Gabriela Balikova Pharmaceuticals (Basel) Article The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protected in a biofilm environment. In this paper, we compare the in vitro activities of two new semisynthetic glycopeptide antibiotics, MA79 and ERJ390, with two clinically used glycopeptide antibiotics—vancomycin and teicoplanin. The new antibiotics effectively killed not only exponentially growing cells of Staphylococcus aureus, but also cells in the stationary growth phase and biofilm. MDPI 2021-11-19 /pmc/articles/PMC8619453/ /pubmed/34832964 http://dx.doi.org/10.3390/ph14111182 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vimberg, Vladimir Zieglerova, Leona Mazumdar, Aninda Szűcs, Zsolt Borbás, Aniko Herczegh, Pál Novotna, Gabriela Balikova Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase |
title | Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase |
title_full | Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase |
title_fullStr | Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase |
title_full_unstemmed | Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase |
title_short | Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase |
title_sort | two novel semisynthetic lipoglycopeptides active against staphylococcus aureus biofilms and cells in late stationary growth phase |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619453/ https://www.ncbi.nlm.nih.gov/pubmed/34832964 http://dx.doi.org/10.3390/ph14111182 |
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