Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots

The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/Zn...

Descripción completa

Detalles Bibliográficos
Autores principales: Ncapayi, Vuyelwa, Ninan, Neethu, Lebepe, Thabang C., Parani, Sundararajan, Girija, Aswathy Ravindran, Bright, Richard, Vasilev, Krasimir, Maluleke, Rodney, Tsolekile, Ncediwe, Kodama, Tetsuya, Oluwafemi, Oluwatobi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619584/
https://www.ncbi.nlm.nih.gov/pubmed/34830396
http://dx.doi.org/10.3390/ijms222212514
_version_ 1784605028768546816
author Ncapayi, Vuyelwa
Ninan, Neethu
Lebepe, Thabang C.
Parani, Sundararajan
Girija, Aswathy Ravindran
Bright, Richard
Vasilev, Krasimir
Maluleke, Rodney
Tsolekile, Ncediwe
Kodama, Tetsuya
Oluwafemi, Oluwatobi S.
author_facet Ncapayi, Vuyelwa
Ninan, Neethu
Lebepe, Thabang C.
Parani, Sundararajan
Girija, Aswathy Ravindran
Bright, Richard
Vasilev, Krasimir
Maluleke, Rodney
Tsolekile, Ncediwe
Kodama, Tetsuya
Oluwafemi, Oluwatobi S.
author_sort Ncapayi, Vuyelwa
collection PubMed
description The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.
format Online
Article
Text
id pubmed-8619584
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86195842021-11-27 Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots Ncapayi, Vuyelwa Ninan, Neethu Lebepe, Thabang C. Parani, Sundararajan Girija, Aswathy Ravindran Bright, Richard Vasilev, Krasimir Maluleke, Rodney Tsolekile, Ncediwe Kodama, Tetsuya Oluwafemi, Oluwatobi S. Int J Mol Sci Article The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer. MDPI 2021-11-19 /pmc/articles/PMC8619584/ /pubmed/34830396 http://dx.doi.org/10.3390/ijms222212514 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ncapayi, Vuyelwa
Ninan, Neethu
Lebepe, Thabang C.
Parani, Sundararajan
Girija, Aswathy Ravindran
Bright, Richard
Vasilev, Krasimir
Maluleke, Rodney
Tsolekile, Ncediwe
Kodama, Tetsuya
Oluwafemi, Oluwatobi S.
Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_full Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_fullStr Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_full_unstemmed Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_short Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
title_sort diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619584/
https://www.ncbi.nlm.nih.gov/pubmed/34830396
http://dx.doi.org/10.3390/ijms222212514
work_keys_str_mv AT ncapayivuyelwa diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT ninanneethu diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT lebepethabangc diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT paranisundararajan diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT girijaaswathyravindran diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT brightrichard diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT vasilevkrasimir diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT malulekerodney diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT tsolekilencediwe diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT kodamatetsuya diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots
AT oluwafemioluwatobis diagnosisofprostatecancerandprostatitisusingnearinfraredfluorescentaginseznsquantumdots

Ejemplares similares