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Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis

Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted...

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Autores principales: Ţarcă, Elena, Roșu, Solange Tamara, Cojocaru, Elena, Trandafir, Laura, Luca, Alina Costina, Lupu, Valeriu Vasile, Moisă, Ștefana Maria, Munteanu, Valentin, Butnariu, Lăcrămioara Ionela, Ţarcă, Viorel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619615/
https://www.ncbi.nlm.nih.gov/pubmed/34834520
http://dx.doi.org/10.3390/jpm11111168
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author Ţarcă, Elena
Roșu, Solange Tamara
Cojocaru, Elena
Trandafir, Laura
Luca, Alina Costina
Lupu, Valeriu Vasile
Moisă, Ștefana Maria
Munteanu, Valentin
Butnariu, Lăcrămioara Ionela
Ţarcă, Viorel
author_facet Ţarcă, Elena
Roșu, Solange Tamara
Cojocaru, Elena
Trandafir, Laura
Luca, Alina Costina
Lupu, Valeriu Vasile
Moisă, Ștefana Maria
Munteanu, Valentin
Butnariu, Lăcrămioara Ionela
Ţarcă, Viorel
author_sort Ţarcă, Elena
collection PubMed
description Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted a retrospective cohort study of neonates with gastroschisis treated in a tertiary pediatric center during the last 30 years; 159 patients were eligible for the study. Logistic regression was used to determine the risk of death, estimated based on independent variables previously validated by the chi-square test. Results: if the birth weight is below normal, then we find an increased risk (4.908 times) of evolution to death. Similarly, the risk of death is 7.782 times higher in the case of developing abdominal compartment syndrome, about 3 times in the case of sepsis and 7.883 times in the case of bronchopneumonia. All four independent variables contributed 47.6% to the risk of death. Conclusion: although in the past 30 years in our country we have seen transformational improvements in outcome of gastroschisis, survival rates increasing from 26% to 52%, some factors may still be ameliorated for a better outcome.
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spelling pubmed-86196152021-11-27 Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis Ţarcă, Elena Roșu, Solange Tamara Cojocaru, Elena Trandafir, Laura Luca, Alina Costina Lupu, Valeriu Vasile Moisă, Ștefana Maria Munteanu, Valentin Butnariu, Lăcrămioara Ionela Ţarcă, Viorel J Pers Med Article Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted a retrospective cohort study of neonates with gastroschisis treated in a tertiary pediatric center during the last 30 years; 159 patients were eligible for the study. Logistic regression was used to determine the risk of death, estimated based on independent variables previously validated by the chi-square test. Results: if the birth weight is below normal, then we find an increased risk (4.908 times) of evolution to death. Similarly, the risk of death is 7.782 times higher in the case of developing abdominal compartment syndrome, about 3 times in the case of sepsis and 7.883 times in the case of bronchopneumonia. All four independent variables contributed 47.6% to the risk of death. Conclusion: although in the past 30 years in our country we have seen transformational improvements in outcome of gastroschisis, survival rates increasing from 26% to 52%, some factors may still be ameliorated for a better outcome. MDPI 2021-11-09 /pmc/articles/PMC8619615/ /pubmed/34834520 http://dx.doi.org/10.3390/jpm11111168 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ţarcă, Elena
Roșu, Solange Tamara
Cojocaru, Elena
Trandafir, Laura
Luca, Alina Costina
Lupu, Valeriu Vasile
Moisă, Ștefana Maria
Munteanu, Valentin
Butnariu, Lăcrămioara Ionela
Ţarcă, Viorel
Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis
title Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis
title_full Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis
title_fullStr Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis
title_full_unstemmed Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis
title_short Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis
title_sort statistical analysis of the main risk factors of an unfavorable evolution in gastroschisis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619615/
https://www.ncbi.nlm.nih.gov/pubmed/34834520
http://dx.doi.org/10.3390/jpm11111168
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