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Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis
Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619615/ https://www.ncbi.nlm.nih.gov/pubmed/34834520 http://dx.doi.org/10.3390/jpm11111168 |
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author | Ţarcă, Elena Roșu, Solange Tamara Cojocaru, Elena Trandafir, Laura Luca, Alina Costina Lupu, Valeriu Vasile Moisă, Ștefana Maria Munteanu, Valentin Butnariu, Lăcrămioara Ionela Ţarcă, Viorel |
author_facet | Ţarcă, Elena Roșu, Solange Tamara Cojocaru, Elena Trandafir, Laura Luca, Alina Costina Lupu, Valeriu Vasile Moisă, Ștefana Maria Munteanu, Valentin Butnariu, Lăcrămioara Ionela Ţarcă, Viorel |
author_sort | Ţarcă, Elena |
collection | PubMed |
description | Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted a retrospective cohort study of neonates with gastroschisis treated in a tertiary pediatric center during the last 30 years; 159 patients were eligible for the study. Logistic regression was used to determine the risk of death, estimated based on independent variables previously validated by the chi-square test. Results: if the birth weight is below normal, then we find an increased risk (4.908 times) of evolution to death. Similarly, the risk of death is 7.782 times higher in the case of developing abdominal compartment syndrome, about 3 times in the case of sepsis and 7.883 times in the case of bronchopneumonia. All four independent variables contributed 47.6% to the risk of death. Conclusion: although in the past 30 years in our country we have seen transformational improvements in outcome of gastroschisis, survival rates increasing from 26% to 52%, some factors may still be ameliorated for a better outcome. |
format | Online Article Text |
id | pubmed-8619615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86196152021-11-27 Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis Ţarcă, Elena Roșu, Solange Tamara Cojocaru, Elena Trandafir, Laura Luca, Alina Costina Lupu, Valeriu Vasile Moisă, Ștefana Maria Munteanu, Valentin Butnariu, Lăcrămioara Ionela Ţarcă, Viorel J Pers Med Article Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted a retrospective cohort study of neonates with gastroschisis treated in a tertiary pediatric center during the last 30 years; 159 patients were eligible for the study. Logistic regression was used to determine the risk of death, estimated based on independent variables previously validated by the chi-square test. Results: if the birth weight is below normal, then we find an increased risk (4.908 times) of evolution to death. Similarly, the risk of death is 7.782 times higher in the case of developing abdominal compartment syndrome, about 3 times in the case of sepsis and 7.883 times in the case of bronchopneumonia. All four independent variables contributed 47.6% to the risk of death. Conclusion: although in the past 30 years in our country we have seen transformational improvements in outcome of gastroschisis, survival rates increasing from 26% to 52%, some factors may still be ameliorated for a better outcome. MDPI 2021-11-09 /pmc/articles/PMC8619615/ /pubmed/34834520 http://dx.doi.org/10.3390/jpm11111168 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ţarcă, Elena Roșu, Solange Tamara Cojocaru, Elena Trandafir, Laura Luca, Alina Costina Lupu, Valeriu Vasile Moisă, Ștefana Maria Munteanu, Valentin Butnariu, Lăcrămioara Ionela Ţarcă, Viorel Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis |
title | Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis |
title_full | Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis |
title_fullStr | Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis |
title_full_unstemmed | Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis |
title_short | Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis |
title_sort | statistical analysis of the main risk factors of an unfavorable evolution in gastroschisis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619615/ https://www.ncbi.nlm.nih.gov/pubmed/34834520 http://dx.doi.org/10.3390/jpm11111168 |
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