How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity

Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechani...

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Detalles Bibliográficos
Autores principales: Lamotte, Laurie-Anne, Tafforeau, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619935/
https://www.ncbi.nlm.nih.gov/pubmed/34835115
http://dx.doi.org/10.3390/v13112309
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author Lamotte, Laurie-Anne
Tafforeau, Lionel
author_facet Lamotte, Laurie-Anne
Tafforeau, Lionel
author_sort Lamotte, Laurie-Anne
collection PubMed
description Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechanisms to counteract this system to perform proper infection. Among IAV proteins, the non-structural protein NS1 is shown to be one of the main virulence factors involved in these viral hijackings. NS1 is notably able to inhibit the host’s antiviral response through the perturbation of ubiquitination in different ways, as discussed in this review.
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spelling pubmed-86199352021-11-27 How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity Lamotte, Laurie-Anne Tafforeau, Lionel Viruses Review Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechanisms to counteract this system to perform proper infection. Among IAV proteins, the non-structural protein NS1 is shown to be one of the main virulence factors involved in these viral hijackings. NS1 is notably able to inhibit the host’s antiviral response through the perturbation of ubiquitination in different ways, as discussed in this review. MDPI 2021-11-19 /pmc/articles/PMC8619935/ /pubmed/34835115 http://dx.doi.org/10.3390/v13112309 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lamotte, Laurie-Anne
Tafforeau, Lionel
How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_full How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_fullStr How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_full_unstemmed How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_short How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_sort how influenza a virus ns1 deals with the ubiquitin system to evade innate immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619935/
https://www.ncbi.nlm.nih.gov/pubmed/34835115
http://dx.doi.org/10.3390/v13112309
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