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Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries

Snakebite-induced acute kidney injury (AKI) is frequently observed in patients following bites from vipers such as Russell’s viper (Daboia russelii) in India. Currently, the levels of serum creatinine are mainly used as a marker to determine the necessity for renal replacement therapy (RRT) (haemodi...

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Autores principales: Senthilkumaran, Subramanian, Patel, Ketan, Salim, Anika, Vijayakumar, Pradeep, Williams, Harry F., Vaiyapuri, Rajendran, Savania, Ravi, Elangovan, Namasivayam, Thirumalaikolundusubramanian, Ponniah, Baksh, M. Fazil, Vaiyapuri, Sakthivel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620021/
https://www.ncbi.nlm.nih.gov/pubmed/34822581
http://dx.doi.org/10.3390/toxins13110797
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author Senthilkumaran, Subramanian
Patel, Ketan
Salim, Anika
Vijayakumar, Pradeep
Williams, Harry F.
Vaiyapuri, Rajendran
Savania, Ravi
Elangovan, Namasivayam
Thirumalaikolundusubramanian, Ponniah
Baksh, M. Fazil
Vaiyapuri, Sakthivel
author_facet Senthilkumaran, Subramanian
Patel, Ketan
Salim, Anika
Vijayakumar, Pradeep
Williams, Harry F.
Vaiyapuri, Rajendran
Savania, Ravi
Elangovan, Namasivayam
Thirumalaikolundusubramanian, Ponniah
Baksh, M. Fazil
Vaiyapuri, Sakthivel
author_sort Senthilkumaran, Subramanian
collection PubMed
description Snakebite-induced acute kidney injury (AKI) is frequently observed in patients following bites from vipers such as Russell’s viper (Daboia russelii) in India. Currently, the levels of serum creatinine are mainly used as a marker to determine the necessity for renal replacement therapy (RRT) (haemodialysis) in severe cases of AKI. However, it takes up to 48 h to ascertain a distinct change in creatinine levels compared to its baseline level upon admission. The time lost between admission and the 48 h timepoint significantly affects the clinical management of snakebite victims. Moreover, early diagnosis of AKI and decision on the necessity for RRT in snakebite victims is critical in saving lives, reducing long-term complications, and minimising treatment costs arising from expensive haemodialysis. Neutrophil gelatinase–associated lipocalin (NGAL) has been recently studied as a robust early marker for AKI in non-snakebite patients. However, its suitability for clinical use in snakebite victims has not been rigorously established. Here, we demonstrate the clinical significance of plasma NGAL as a robust marker for RRT following AKI using a large cohort (309) of Russell’s viper victims without any pre-existing health conditions. NGAL levels upon admission are positively correlated with creatinine levels at 48 h in different stages of AKI. Overall, NGAL acts as a robust early marker to ascertain the need for RRT following Russell’s viper bites. The quantification of NGAL can be recommended as a routine test in hospitals that treat snakebites to decide on RRT at early time points instead of waiting for 48 h to confirm the increase in creatinine levels. The diagnostic use of NGAL in Russell’s viper victims with pre-existing comorbidities and for other vipers should be evaluated in future studies.
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spelling pubmed-86200212021-11-27 Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries Senthilkumaran, Subramanian Patel, Ketan Salim, Anika Vijayakumar, Pradeep Williams, Harry F. Vaiyapuri, Rajendran Savania, Ravi Elangovan, Namasivayam Thirumalaikolundusubramanian, Ponniah Baksh, M. Fazil Vaiyapuri, Sakthivel Toxins (Basel) Article Snakebite-induced acute kidney injury (AKI) is frequently observed in patients following bites from vipers such as Russell’s viper (Daboia russelii) in India. Currently, the levels of serum creatinine are mainly used as a marker to determine the necessity for renal replacement therapy (RRT) (haemodialysis) in severe cases of AKI. However, it takes up to 48 h to ascertain a distinct change in creatinine levels compared to its baseline level upon admission. The time lost between admission and the 48 h timepoint significantly affects the clinical management of snakebite victims. Moreover, early diagnosis of AKI and decision on the necessity for RRT in snakebite victims is critical in saving lives, reducing long-term complications, and minimising treatment costs arising from expensive haemodialysis. Neutrophil gelatinase–associated lipocalin (NGAL) has been recently studied as a robust early marker for AKI in non-snakebite patients. However, its suitability for clinical use in snakebite victims has not been rigorously established. Here, we demonstrate the clinical significance of plasma NGAL as a robust marker for RRT following AKI using a large cohort (309) of Russell’s viper victims without any pre-existing health conditions. NGAL levels upon admission are positively correlated with creatinine levels at 48 h in different stages of AKI. Overall, NGAL acts as a robust early marker to ascertain the need for RRT following Russell’s viper bites. The quantification of NGAL can be recommended as a routine test in hospitals that treat snakebites to decide on RRT at early time points instead of waiting for 48 h to confirm the increase in creatinine levels. The diagnostic use of NGAL in Russell’s viper victims with pre-existing comorbidities and for other vipers should be evaluated in future studies. MDPI 2021-11-12 /pmc/articles/PMC8620021/ /pubmed/34822581 http://dx.doi.org/10.3390/toxins13110797 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Senthilkumaran, Subramanian
Patel, Ketan
Salim, Anika
Vijayakumar, Pradeep
Williams, Harry F.
Vaiyapuri, Rajendran
Savania, Ravi
Elangovan, Namasivayam
Thirumalaikolundusubramanian, Ponniah
Baksh, M. Fazil
Vaiyapuri, Sakthivel
Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries
title Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries
title_full Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries
title_fullStr Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries
title_full_unstemmed Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries
title_short Neutrophil Gelatinase–Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell’s Viper Bite–Induced Acute Kidney Injuries
title_sort neutrophil gelatinase–associated lipocalin acts as a robust early diagnostic marker for renal replacement therapy in patients with russell’s viper bite–induced acute kidney injuries
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620021/
https://www.ncbi.nlm.nih.gov/pubmed/34822581
http://dx.doi.org/10.3390/toxins13110797
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