Cargando…

The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice

Patients with psoriatic arthritis (PsA) often develop joint symptoms years after their initial diagnosis of psoriasis disease; therefore, dermatologists should test for and detect PsA early. In this study, we focused on patients with psoriasis with both nail and joint disease being treated with tumo...

Descripción completa

Detalles Bibliográficos
Autores principales: Kokolakis, Georgios, Sabat, Robert, Fischer, Imma, Gomis-Kleindienst, Susana, Fritz, Björn, Burmester, Gerd-Rüdiger, Ghoreschi, Kamran, Ohrndorf, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620057/
https://www.ncbi.nlm.nih.gov/pubmed/34834435
http://dx.doi.org/10.3390/jpm11111083
_version_ 1784605133430063104
author Kokolakis, Georgios
Sabat, Robert
Fischer, Imma
Gomis-Kleindienst, Susana
Fritz, Björn
Burmester, Gerd-Rüdiger
Ghoreschi, Kamran
Ohrndorf, Sarah
author_facet Kokolakis, Georgios
Sabat, Robert
Fischer, Imma
Gomis-Kleindienst, Susana
Fritz, Björn
Burmester, Gerd-Rüdiger
Ghoreschi, Kamran
Ohrndorf, Sarah
author_sort Kokolakis, Georgios
collection PubMed
description Patients with psoriatic arthritis (PsA) often develop joint symptoms years after their initial diagnosis of psoriasis disease; therefore, dermatologists should test for and detect PsA early. In this study, we focused on patients with psoriasis with both nail and joint disease being treated with tumor necrosis factor-α inhibitors by dermatologists. We performed a noninterventional, prospective, multicenter, and open-label study to evaluate the effectiveness of adalimumab, etanercept, or infliximab over 24 months of continuous therapy in patients with moderate to severe plaque-type psoriasis (Pso) and PsA. Disease assessments with the Psoriasis Area and Severity Index, Nail Psoriasis Severity Index (NAPSI), joint assessment, Dermatology Life Quality Index (DLQI), and Health Assessment Questionnaire (HAQ) instruments were performed every 3 months for the first year and twice annually thereafter. The cohort included 100 patients with Pso, nail psoriasis, and PsA. A significant reduction of NAPSI was observed 3 months after therapy initiation compared with the baseline (mean ± SD, 22.9 ± 17.8 vs. 33.8 ± 21.4; p < 0.001). Similarly, the mean ± SD number of both tender and swollen joints decreased significantly within the first 3 months of treatment, from 10.8 ± 11.5 to 6.4 ± 10.3 (p < 0.001) and from 6.4 ± 9.5 to 3.1 ± 7.2 (p < 0.001), respectively. Additionally, the distal interphalangeal joint involvement improved throughout the observation time, and DLQI and HAQ scores decreased. Improvements in control of skin, nail, and joint symptoms were seen, as well as in patients’ quality of life and functionality. Dermatologists have an important role not only in PsA diagnosis but also in PsA long-term care.
format Online
Article
Text
id pubmed-8620057
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86200572021-11-27 The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice Kokolakis, Georgios Sabat, Robert Fischer, Imma Gomis-Kleindienst, Susana Fritz, Björn Burmester, Gerd-Rüdiger Ghoreschi, Kamran Ohrndorf, Sarah J Pers Med Article Patients with psoriatic arthritis (PsA) often develop joint symptoms years after their initial diagnosis of psoriasis disease; therefore, dermatologists should test for and detect PsA early. In this study, we focused on patients with psoriasis with both nail and joint disease being treated with tumor necrosis factor-α inhibitors by dermatologists. We performed a noninterventional, prospective, multicenter, and open-label study to evaluate the effectiveness of adalimumab, etanercept, or infliximab over 24 months of continuous therapy in patients with moderate to severe plaque-type psoriasis (Pso) and PsA. Disease assessments with the Psoriasis Area and Severity Index, Nail Psoriasis Severity Index (NAPSI), joint assessment, Dermatology Life Quality Index (DLQI), and Health Assessment Questionnaire (HAQ) instruments were performed every 3 months for the first year and twice annually thereafter. The cohort included 100 patients with Pso, nail psoriasis, and PsA. A significant reduction of NAPSI was observed 3 months after therapy initiation compared with the baseline (mean ± SD, 22.9 ± 17.8 vs. 33.8 ± 21.4; p < 0.001). Similarly, the mean ± SD number of both tender and swollen joints decreased significantly within the first 3 months of treatment, from 10.8 ± 11.5 to 6.4 ± 10.3 (p < 0.001) and from 6.4 ± 9.5 to 3.1 ± 7.2 (p < 0.001), respectively. Additionally, the distal interphalangeal joint involvement improved throughout the observation time, and DLQI and HAQ scores decreased. Improvements in control of skin, nail, and joint symptoms were seen, as well as in patients’ quality of life and functionality. Dermatologists have an important role not only in PsA diagnosis but also in PsA long-term care. MDPI 2021-10-25 /pmc/articles/PMC8620057/ /pubmed/34834435 http://dx.doi.org/10.3390/jpm11111083 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kokolakis, Georgios
Sabat, Robert
Fischer, Imma
Gomis-Kleindienst, Susana
Fritz, Björn
Burmester, Gerd-Rüdiger
Ghoreschi, Kamran
Ohrndorf, Sarah
The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice
title The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice
title_full The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice
title_fullStr The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice
title_full_unstemmed The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice
title_short The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice
title_sort effect of tnf-α inhibitors on nail psoriasis and psoriatic arthritis—real-world data from dermatology practice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620057/
https://www.ncbi.nlm.nih.gov/pubmed/34834435
http://dx.doi.org/10.3390/jpm11111083
work_keys_str_mv AT kokolakisgeorgios theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT sabatrobert theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT fischerimma theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT gomiskleindienstsusana theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT fritzbjorn theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT burmestergerdrudiger theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT ghoreschikamran theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT ohrndorfsarah theeffectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT kokolakisgeorgios effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT sabatrobert effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT fischerimma effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT gomiskleindienstsusana effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT fritzbjorn effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT burmestergerdrudiger effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT ghoreschikamran effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice
AT ohrndorfsarah effectoftnfainhibitorsonnailpsoriasisandpsoriaticarthritisrealworlddatafromdermatologypractice