New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27

In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already...

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Autores principales: Paulus, Constanze, Gromyko, Oleksandr, Luzhetskyy, Andriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620246/
https://www.ncbi.nlm.nih.gov/pubmed/34833926
http://dx.doi.org/10.3390/molecules26226834
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author Paulus, Constanze
Gromyko, Oleksandr
Luzhetskyy, Andriy
author_facet Paulus, Constanze
Gromyko, Oleksandr
Luzhetskyy, Andriy
author_sort Paulus, Constanze
collection PubMed
description In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of Streptomyces sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools.
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spelling pubmed-86202462021-11-27 New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27 Paulus, Constanze Gromyko, Oleksandr Luzhetskyy, Andriy Molecules Article In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of Streptomyces sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools. MDPI 2021-11-12 /pmc/articles/PMC8620246/ /pubmed/34833926 http://dx.doi.org/10.3390/molecules26226834 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paulus, Constanze
Gromyko, Oleksandr
Luzhetskyy, Andriy
New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27
title New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27
title_full New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27
title_fullStr New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27
title_full_unstemmed New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27
title_short New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27
title_sort new kendomycin derivative isolated from streptomyces sp. cl 58-27
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620246/
https://www.ncbi.nlm.nih.gov/pubmed/34833926
http://dx.doi.org/10.3390/molecules26226834
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