Cargando…

Transcriptional Profiles of Cell Fate Transitions Reveal Early Drivers of Neuronal Apoptosis and Survival

Neuronal apoptosis and survival are regulated at the transcriptional level. To identify key genes and upstream regulators primarily responsible for these processes, we overlayed the temporal transcriptome of cerebellar granule neurons following induction of apoptosis and their rescue by three differ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morello, Giovanna, Villari, Ambra, Spampinato, Antonio Gianmaria, La Cognata, Valentina, Guarnaccia, Maria, Gentile, Giulia, Ciotti, Maria Teresa, Calissano, Pietro, D’Agata, Velia, Severini, Cinzia, Cavallaro, Sebastiano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620386/ https://www.ncbi.nlm.nih.gov/pubmed/34831459 http://dx.doi.org/10.3390/cells10113238

Ejemplares similares

Cracking the Code of Neuronal Cell Fate
por: Morello, Giovanna, et al.
Publicado: (2023)

Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach
por: Morello, Giovanna, et al.
Publicado: (2017)

Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS
por: Morello, Giovanna, et al.
Publicado: (2019)

Selection and Prioritization of Candidate Drug Targets for Amyotrophic Lateral Sclerosis Through a Meta-Analysis Approach
por: Morello, Giovanna, et al.
Publicado: (2017)

Copy number variability in Parkinson’s disease: assembling the puzzle through a systems biology approach
por: La Cognata, Valentina, et al.
Publicado: (2016)

A customized high-resolution array-comparative genomic hybridization to explore copy number variations in Parkinson’s disease
por: La Cognata, Valentina, et al.
Publicado: (2016)

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment
por: Morello, Giovanna, et al.
Publicado: (2023)

CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A
por: La Cognata, Valentina, et al.
Publicado: (2023)

The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells
por: La Cognata, Valentina, et al.
Publicado: (2023)

Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
por: Gentile, Giulia, et al.
Publicado: (2022)

Transcriptional landscapes at the intersection of neuronal apoptosis and substance P-induced survival: exploring pathways and drug targets
por: Paparone, S, et al.
Publicado: (2016)

Splicing: is there an alternative contribution to Parkinson’s disease?
por: La Cognata, Valentina, et al.
Publicado: (2015)

Design and Validation of a Custom NGS Panel Targeting a Set of Lysosomal Storage Diseases Candidate for NBS Applications
por: La Cognata, Valentina, et al.
Publicado: (2021)

NeuroArray, A Custom CGH Microarray to Decipher Copy Number Variants in Alzheimer’s Disease
por: Cuccaro, Denis, et al.
Publicado: (2018)

Genomic Portrait of a Sporadic Amyotrophic Lateral Sclerosis Case in a Large Spinocerebellar Ataxia Type 1 Family
por: Morello, Giovanna, et al.
Publicado: (2020)

Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain
por: Scuderi, Soraya, et al.
Publicado: (2014)

From Multi-Omics Approaches to Precision Medicine in Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2020)

Molecular Taxonomy of Sporadic Amyotrophic Lateral Sclerosis Using Disease-Associated Genes
por: Morello, Giovanna, et al.
Publicado: (2017)

Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic Targets
por: Morello, Giovanna, et al.
Publicado: (2017)

Transcriptional Analysis of Apoptotic Cerebellar Granule Neurons Following Rescue by Gastric Inhibitory Polypeptide
por: Maino, Barbara, et al.
Publicado: (2014)

NeuroArray: A Customized aCGH for the Analysis of Copy Number Variations in Neurological Disorders
por: La Cognata, Valentina, et al.
Publicado: (2018)

Differential Vulnerability of Oculomotor Versus Hypoglossal Nucleus During ALS: Involvement of PACAP
por: Maugeri, Grazia, et al.
Publicado: (2020)

Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene
por: Cognata, Valentina La, et al.
Publicado: (2014)

Development of a Pharmacogenetic Lab-on-Chip Assay Based on the In-Check Technology to Screen for Genetic Variations Associated to Adverse Drug Reactions to Common Chemotherapeutic Agents
por: Iemmolo, Rosario, et al.
Publicado: (2020)

A Diagnostic Gene-Expression Signature in Fibroblasts of Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2023)

Highlights on Genomics Applications for Lysosomal Storage Diseases
por: La Cognata, Valentina, et al.
Publicado: (2020)

Taxonomy Meets Neurology, the Case of Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2018)

Involvement of Bradykinin Receptor 2 in Nerve Growth Factor Neuroprotective Activity
por: Petrella, Carla, et al.
Publicado: (2020)

Igf1 and Pacap rescue cerebellar granule neurons from apoptosis via a common transcriptional program
por: Maino, B, et al.
Publicado: (2015)

Detection of Single-Nucleotide and Copy Number Defects Underlying Hyperphenylalaninemia by Next-Generation Sequencing
por: Tendi, Elisabetta Anna, et al.
Publicado: (2023)

Omics Data and Their Integrative Analysis to Support Stratified Medicine in Neurodegenerative Diseases
por: La Cognata, Valentina, et al.
Publicado: (2021)

iPSCs: A Preclinical Drug Research Tool for Neurological Disorders
por: Bonaventura, Gabriele, et al.
Publicado: (2021)

The Utility of Genomic Testing for Hyperphenylalaninemia
por: Tendi, Elisabetta Anna, et al.
Publicado: (2022)

miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis
por: Gentile, Giulia, et al.
Publicado: (2021)

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions
por: La Cognata, Valentina, et al.
Publicado: (2020)

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology
por: Canu, Nadia, et al.
Publicado: (2017)

PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression
por: Maugeri, Grazia, et al.
Publicado: (2016)

PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis
por: D’Amico, Agata Grazia, et al.
Publicado: (2020)

A Targeted Next-Generation Sequencing Panel to Genotype Gliomas
por: Guarnaccia, Maria, et al.
Publicado: (2022)

Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway
por: Fetoni, Anna Rita, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_sc69ot7u4jm0ghuih4snq3dufl