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Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers

In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-d,l lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage...

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Autores principales: Shim, Ha-Eun, Yeon, Yeong-Heum, Lim, Dae-Hee, Nam, You-Ree, Park, Jin-Hyung, Lee, Nam-Ho, Gwon, Hui-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620408/
https://www.ncbi.nlm.nih.gov/pubmed/34832188
http://dx.doi.org/10.3390/ma14226777
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author Shim, Ha-Eun
Yeon, Yeong-Heum
Lim, Dae-Hee
Nam, You-Ree
Park, Jin-Hyung
Lee, Nam-Ho
Gwon, Hui-Jeong
author_facet Shim, Ha-Eun
Yeon, Yeong-Heum
Lim, Dae-Hee
Nam, You-Ree
Park, Jin-Hyung
Lee, Nam-Ho
Gwon, Hui-Jeong
author_sort Shim, Ha-Eun
collection PubMed
description In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-d,l lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage model, both chain scission and crosslinking reactions appear to occur at a radiation dose in the range 0–200 kGy, but the chain cleavage reaction is expected to be relatively dominant at high irradiation doses above 500 kGy. On the other hand, the PLDLA damage model predicted that the chain cleavage reaction would prevail at the total irradiation dose (25–500 kGy). To verify the simulation results, the physicochemical changes in the irradiated PLCL and PLDLA films were characterized by GPC (gel permeation chromatography), ATR-FTIR (attenuated total reflection Fourier transform infrared), and DSC (difference scanning calorimetry) analyses. The Geant4 simulation curve for the radiation-induced damage to the molecular weight was consistent with the experimentally obtained results. These results imply that the pre-simulation study can be useful for predicting the optimal irradiation dose and ensuring material safety, particularly for implanted biodegradable materials in radiation processing.
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spelling pubmed-86204082021-11-27 Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers Shim, Ha-Eun Yeon, Yeong-Heum Lim, Dae-Hee Nam, You-Ree Park, Jin-Hyung Lee, Nam-Ho Gwon, Hui-Jeong Materials (Basel) Article In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-d,l lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage model, both chain scission and crosslinking reactions appear to occur at a radiation dose in the range 0–200 kGy, but the chain cleavage reaction is expected to be relatively dominant at high irradiation doses above 500 kGy. On the other hand, the PLDLA damage model predicted that the chain cleavage reaction would prevail at the total irradiation dose (25–500 kGy). To verify the simulation results, the physicochemical changes in the irradiated PLCL and PLDLA films were characterized by GPC (gel permeation chromatography), ATR-FTIR (attenuated total reflection Fourier transform infrared), and DSC (difference scanning calorimetry) analyses. The Geant4 simulation curve for the radiation-induced damage to the molecular weight was consistent with the experimentally obtained results. These results imply that the pre-simulation study can be useful for predicting the optimal irradiation dose and ensuring material safety, particularly for implanted biodegradable materials in radiation processing. MDPI 2021-11-10 /pmc/articles/PMC8620408/ /pubmed/34832188 http://dx.doi.org/10.3390/ma14226777 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shim, Ha-Eun
Yeon, Yeong-Heum
Lim, Dae-Hee
Nam, You-Ree
Park, Jin-Hyung
Lee, Nam-Ho
Gwon, Hui-Jeong
Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_full Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_fullStr Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_full_unstemmed Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_short Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_sort preliminary study on the simulation of a radiation damage analysis of biodegradable polymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620408/
https://www.ncbi.nlm.nih.gov/pubmed/34832188
http://dx.doi.org/10.3390/ma14226777
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