Synthesis, Characterization, and Intrinsic Dissolution Studies of Drug–Drug Eutectic Solid Forms of Metformin Hydrochloride and Thiazide Diuretics

The mechanochemical synthesis of drug–drug solid forms containing metformin hydrochloride (MET·HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported. Characterization of these new systems indicates formation of binary eutectic conglomerates, i.e., drug–drug eutect...

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Detalles Bibliográficos
Autores principales: Coyote-Dotor, Guadalupe, Páez-Franco, José C., Canseco-González, Daniel, Núñez-Pineda, Alejandra, Dorazco-González, Alejandro, Fuentes-Noriega, Inés, Vilchis-Néstor, Alfredo R., Rodríguez-Hernández, Joelis, Morales-Morales, David, Germán-Acacio, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620433/
https://www.ncbi.nlm.nih.gov/pubmed/34834341
http://dx.doi.org/10.3390/pharmaceutics13111926

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