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The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection

BACKGROUND: Mitochondrial DNA (mtDNA) codes for products necessary for electron transport and mitochondrial gene translation. mtDNA mutations can lead to human disease and influence organismal fitness. The PolG mutator mouse lacks mtDNA proofreading function and rapidly accumulates mtDNA mutations,...

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Detalles Bibliográficos
Autores principales:	Maclaine, Kendra D., Stebbings, Kevin A., Llano, Daniel A., Havird, Justin C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620558/ https://www.ncbi.nlm.nih.gov/pubmed/34823474 http://dx.doi.org/10.1186/s12863-021-01005-x

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