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Leishmania and the Model of Predominant Clonal Evolution

As it is the case for other pathogenic microorganisms, the respective impact of clonality and genetic exchange on Leishmania natural populations has been the object of lively debates since the early 1980s. The predominant clonal evolution (PCE) model states that genetic exchange in these parasites’...

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Autores principales: Tibayrenc, Michel, Ayala, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620605/
https://www.ncbi.nlm.nih.gov/pubmed/34835534
http://dx.doi.org/10.3390/microorganisms9112409
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author Tibayrenc, Michel
Ayala, Francisco J.
author_facet Tibayrenc, Michel
Ayala, Francisco J.
author_sort Tibayrenc, Michel
collection PubMed
description As it is the case for other pathogenic microorganisms, the respective impact of clonality and genetic exchange on Leishmania natural populations has been the object of lively debates since the early 1980s. The predominant clonal evolution (PCE) model states that genetic exchange in these parasites’ natural populations may have a high relevance on an evolutionary scale, but is not sufficient to erase a persistent phylogenetic signal and the existence of bifurcating trees. Recent data based on high-resolution markers and genomic polymorphisms fully confirm the PCE model down to a microevolutionary level.
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spelling pubmed-86206052021-11-27 Leishmania and the Model of Predominant Clonal Evolution Tibayrenc, Michel Ayala, Francisco J. Microorganisms Article As it is the case for other pathogenic microorganisms, the respective impact of clonality and genetic exchange on Leishmania natural populations has been the object of lively debates since the early 1980s. The predominant clonal evolution (PCE) model states that genetic exchange in these parasites’ natural populations may have a high relevance on an evolutionary scale, but is not sufficient to erase a persistent phylogenetic signal and the existence of bifurcating trees. Recent data based on high-resolution markers and genomic polymorphisms fully confirm the PCE model down to a microevolutionary level. MDPI 2021-11-22 /pmc/articles/PMC8620605/ /pubmed/34835534 http://dx.doi.org/10.3390/microorganisms9112409 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tibayrenc, Michel
Ayala, Francisco J.
Leishmania and the Model of Predominant Clonal Evolution
title Leishmania and the Model of Predominant Clonal Evolution
title_full Leishmania and the Model of Predominant Clonal Evolution
title_fullStr Leishmania and the Model of Predominant Clonal Evolution
title_full_unstemmed Leishmania and the Model of Predominant Clonal Evolution
title_short Leishmania and the Model of Predominant Clonal Evolution
title_sort leishmania and the model of predominant clonal evolution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620605/
https://www.ncbi.nlm.nih.gov/pubmed/34835534
http://dx.doi.org/10.3390/microorganisms9112409
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