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Leishmania and the Model of Predominant Clonal Evolution
As it is the case for other pathogenic microorganisms, the respective impact of clonality and genetic exchange on Leishmania natural populations has been the object of lively debates since the early 1980s. The predominant clonal evolution (PCE) model states that genetic exchange in these parasites’...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620605/ https://www.ncbi.nlm.nih.gov/pubmed/34835534 http://dx.doi.org/10.3390/microorganisms9112409 |
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author | Tibayrenc, Michel Ayala, Francisco J. |
author_facet | Tibayrenc, Michel Ayala, Francisco J. |
author_sort | Tibayrenc, Michel |
collection | PubMed |
description | As it is the case for other pathogenic microorganisms, the respective impact of clonality and genetic exchange on Leishmania natural populations has been the object of lively debates since the early 1980s. The predominant clonal evolution (PCE) model states that genetic exchange in these parasites’ natural populations may have a high relevance on an evolutionary scale, but is not sufficient to erase a persistent phylogenetic signal and the existence of bifurcating trees. Recent data based on high-resolution markers and genomic polymorphisms fully confirm the PCE model down to a microevolutionary level. |
format | Online Article Text |
id | pubmed-8620605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86206052021-11-27 Leishmania and the Model of Predominant Clonal Evolution Tibayrenc, Michel Ayala, Francisco J. Microorganisms Article As it is the case for other pathogenic microorganisms, the respective impact of clonality and genetic exchange on Leishmania natural populations has been the object of lively debates since the early 1980s. The predominant clonal evolution (PCE) model states that genetic exchange in these parasites’ natural populations may have a high relevance on an evolutionary scale, but is not sufficient to erase a persistent phylogenetic signal and the existence of bifurcating trees. Recent data based on high-resolution markers and genomic polymorphisms fully confirm the PCE model down to a microevolutionary level. MDPI 2021-11-22 /pmc/articles/PMC8620605/ /pubmed/34835534 http://dx.doi.org/10.3390/microorganisms9112409 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tibayrenc, Michel Ayala, Francisco J. Leishmania and the Model of Predominant Clonal Evolution |
title | Leishmania and the Model of Predominant Clonal Evolution |
title_full | Leishmania and the Model of Predominant Clonal Evolution |
title_fullStr | Leishmania and the Model of Predominant Clonal Evolution |
title_full_unstemmed | Leishmania and the Model of Predominant Clonal Evolution |
title_short | Leishmania and the Model of Predominant Clonal Evolution |
title_sort | leishmania and the model of predominant clonal evolution |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620605/ https://www.ncbi.nlm.nih.gov/pubmed/34835534 http://dx.doi.org/10.3390/microorganisms9112409 |
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