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Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinica...

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Autores principales: Eldridge, Sandy, Scuteri, Arianna, Jones, Eugenia M. C., Cavaletti, Guido, Guo, Liang, Glaze, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620674/
https://www.ncbi.nlm.nih.gov/pubmed/34822690
http://dx.doi.org/10.3390/toxics9110300
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author Eldridge, Sandy
Scuteri, Arianna
Jones, Eugenia M. C.
Cavaletti, Guido
Guo, Liang
Glaze, Elizabeth
author_facet Eldridge, Sandy
Scuteri, Arianna
Jones, Eugenia M. C.
Cavaletti, Guido
Guo, Liang
Glaze, Elizabeth
author_sort Eldridge, Sandy
collection PubMed
description Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinical symptoms of CIPN, and the cellular and molecular targets involved in CIPN, are just as diverse as the wide variety of anticancer agents that cause peripheral neurotoxicity. There is an urgent need for extensive molecular and functional investigations aimed at understanding the mechanisms of CIPN. Furthermore, a reliable human cell culture system that recapitulates the diversity of neuronal modalities found in vivo and the pathophysiological changes that underlie CIPN would serve to advance the understanding of the pathogenesis of CIPN. The demonstration of experimental reproducibility in a human peripheral neuronal cell system will increase confidence that such an in vitro model is clinically useful, ultimately resulting in deeper exploration for the prevention and treatment of CIPN. Herein, we review current in vitro models with a focus on key characteristics and attributes desirable for an ideal human cell culture model relevant for CIPN investigations.
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spelling pubmed-86206742021-11-27 Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy Eldridge, Sandy Scuteri, Arianna Jones, Eugenia M. C. Cavaletti, Guido Guo, Liang Glaze, Elizabeth Toxics Review Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinical symptoms of CIPN, and the cellular and molecular targets involved in CIPN, are just as diverse as the wide variety of anticancer agents that cause peripheral neurotoxicity. There is an urgent need for extensive molecular and functional investigations aimed at understanding the mechanisms of CIPN. Furthermore, a reliable human cell culture system that recapitulates the diversity of neuronal modalities found in vivo and the pathophysiological changes that underlie CIPN would serve to advance the understanding of the pathogenesis of CIPN. The demonstration of experimental reproducibility in a human peripheral neuronal cell system will increase confidence that such an in vitro model is clinically useful, ultimately resulting in deeper exploration for the prevention and treatment of CIPN. Herein, we review current in vitro models with a focus on key characteristics and attributes desirable for an ideal human cell culture model relevant for CIPN investigations. MDPI 2021-11-11 /pmc/articles/PMC8620674/ /pubmed/34822690 http://dx.doi.org/10.3390/toxics9110300 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eldridge, Sandy
Scuteri, Arianna
Jones, Eugenia M. C.
Cavaletti, Guido
Guo, Liang
Glaze, Elizabeth
Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_full Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_fullStr Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_full_unstemmed Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_short Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy
title_sort considerations for a reliable in vitro model of chemotherapy-induced peripheral neuropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620674/
https://www.ncbi.nlm.nih.gov/pubmed/34822690
http://dx.doi.org/10.3390/toxics9110300
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