Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures

Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones w...

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Autores principales: Mikolasch, Annett, Hahn, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620746/
https://www.ncbi.nlm.nih.gov/pubmed/34835324
http://dx.doi.org/10.3390/microorganisms9112199
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author Mikolasch, Annett
Hahn, Veronika
author_facet Mikolasch, Annett
Hahn, Veronika
author_sort Mikolasch, Annett
collection PubMed
description Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.
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spelling pubmed-86207462021-11-27 Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures Mikolasch, Annett Hahn, Veronika Microorganisms Article Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains. MDPI 2021-10-21 /pmc/articles/PMC8620746/ /pubmed/34835324 http://dx.doi.org/10.3390/microorganisms9112199 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mikolasch, Annett
Hahn, Veronika
Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_full Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_fullStr Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_full_unstemmed Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_short Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_sort laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620746/
https://www.ncbi.nlm.nih.gov/pubmed/34835324
http://dx.doi.org/10.3390/microorganisms9112199
work_keys_str_mv AT mikolaschannett laccasecatalyzedderivatizationofantibioticswithsulfonamideorsulfonestructures
AT hahnveronika laccasecatalyzedderivatizationofantibioticswithsulfonamideorsulfonestructures

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