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Nanoparticles for Ferroptosis Therapy in Cancer

Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability...

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Detalles Bibliográficos
Autores principales: Zaffaroni, Nadia, Beretta, Giovanni Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620841/
https://www.ncbi.nlm.nih.gov/pubmed/34834199
http://dx.doi.org/10.3390/pharmaceutics13111785
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author Zaffaroni, Nadia
Beretta, Giovanni Luca
author_facet Zaffaroni, Nadia
Beretta, Giovanni Luca
author_sort Zaffaroni, Nadia
collection PubMed
description Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy.
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spelling pubmed-86208412021-11-27 Nanoparticles for Ferroptosis Therapy in Cancer Zaffaroni, Nadia Beretta, Giovanni Luca Pharmaceutics Review Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy. MDPI 2021-10-25 /pmc/articles/PMC8620841/ /pubmed/34834199 http://dx.doi.org/10.3390/pharmaceutics13111785 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zaffaroni, Nadia
Beretta, Giovanni Luca
Nanoparticles for Ferroptosis Therapy in Cancer
title Nanoparticles for Ferroptosis Therapy in Cancer
title_full Nanoparticles for Ferroptosis Therapy in Cancer
title_fullStr Nanoparticles for Ferroptosis Therapy in Cancer
title_full_unstemmed Nanoparticles for Ferroptosis Therapy in Cancer
title_short Nanoparticles for Ferroptosis Therapy in Cancer
title_sort nanoparticles for ferroptosis therapy in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620841/
https://www.ncbi.nlm.nih.gov/pubmed/34834199
http://dx.doi.org/10.3390/pharmaceutics13111785
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