Cargando…

The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran

Acceptance and willingness to receive the vaccine are among the main factors in the success or failure of a health system in implementing the vaccination program. The present study was conducted in Tehran, the political and economic capital of Iran, to determine the acceptance of the COVID-19 vaccin...

Descripción completa

Detalles Bibliográficos
Autores principales: Khankeh, Hamid Reza, Farrokhi, Mehrdad, Khanjani, Mohammad Saeed, Momtaz, Yadollah Abolfathi, Forouzan, Ameneh Setareh, Norouzi, Mehdi, Ahmadi, Shokoufeh, Harouni, Gholamreza Ghaedamini, Roudini, Juliet, Ghanaatpisheh, Elham, Hamedanchi, Arya, Pourebrahimi, Mohammad, Alipour, Fardin, Ranjbar, Maryam, Naghikhani, Mehrdad, Saatchi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620861/
https://www.ncbi.nlm.nih.gov/pubmed/34835179
http://dx.doi.org/10.3390/vaccines9111248
_version_ 1784605320928034816
author Khankeh, Hamid Reza
Farrokhi, Mehrdad
Khanjani, Mohammad Saeed
Momtaz, Yadollah Abolfathi
Forouzan, Ameneh Setareh
Norouzi, Mehdi
Ahmadi, Shokoufeh
Harouni, Gholamreza Ghaedamini
Roudini, Juliet
Ghanaatpisheh, Elham
Hamedanchi, Arya
Pourebrahimi, Mohammad
Alipour, Fardin
Ranjbar, Maryam
Naghikhani, Mehrdad
Saatchi, Mohammad
author_facet Khankeh, Hamid Reza
Farrokhi, Mehrdad
Khanjani, Mohammad Saeed
Momtaz, Yadollah Abolfathi
Forouzan, Ameneh Setareh
Norouzi, Mehdi
Ahmadi, Shokoufeh
Harouni, Gholamreza Ghaedamini
Roudini, Juliet
Ghanaatpisheh, Elham
Hamedanchi, Arya
Pourebrahimi, Mohammad
Alipour, Fardin
Ranjbar, Maryam
Naghikhani, Mehrdad
Saatchi, Mohammad
author_sort Khankeh, Hamid Reza
collection PubMed
description Acceptance and willingness to receive the vaccine are among the main factors in the success or failure of a health system in implementing the vaccination program. The present study was conducted in Tehran, the political and economic capital of Iran, to determine the acceptance of the COVID-19 vaccine and identify its associated factors, and explain the most important barriers and acceptance strategies for vaccination. This research was a concurrent quantitative and qualitative mixed-method study. In the quantitative part, 1200 individuals aged more than 18 years were selected from the households in 22 districts of Tehran City, with a multistage stratified cluster sampling method. Two questionnaires were used to evaluate the acceptance of the COVID-19 vaccine and vaccine acceptance determinants. The qualitative content analysis method addressed the influencing factors, as well as challenges and strategies related to the acceptance of the COVID-19 vaccine in four groups of Tehran inhabitants: the elderly, people with underlying diseases, healthcare workers, and the general population. The related data were simultaneously collected by applying in-depth semi-structural interviews and a data analysis process. Furthermore, we used the Graneheim and Lundman method for data analysis. We analyzed the data of 1200 people with a mean (SD) age of 46.4 (11.1) years, and approximately 58% of them were men. The vaccine acceptance was 83.6% (95% CI: 81.3–85.9). Among those who welcomed vaccination, 58% preferred the imported vaccines, 25% the Iranian ones, and 17% both. There was a significant association between the variables of age (adjusted odds ratio [AOR] = 1.72, 95% CI: 1.01–2.93), being single (AOR = 0.54, 95% CI: 0.41–0.91), moderate pharmacotherapy adherence (AOR = 0.58, 95% CI: 0.4–0.85), and the willingness to receive COVID-19 vaccine. Qualitative study after interviewing 45 people from four study groups showed an insufficient social trust in healthcare system officials, pharmaceutical and vaccine production companies; distrust in the effectiveness of the vaccines, concerns about the vaccine adverse effects, being tracked by microchips after vaccination, traditional anti-vaccination movements, the feeling the inessentiality of vaccination, and uncertainty about the fair distribution of the vaccine. These concerns were the main challenges addressed by the study groups. A good proportion of Tehran residents reported their willingness to receive the COVID-19 vaccine. Additionally, they expressed their critical concerns, such as insufficient trust in the healthcare system, vaccine safeties, and adverse effects that were the significant barriers to vaccine acceptance. It seems that conflicts raised by the shortage of vaccines and their import due to the sanctions have led to intense desire and demand in the general population, and especially the elderly, for vaccination. Besides, vaccination phobia in some individuals requires further investigations.
format Online
Article
Text
id pubmed-8620861
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86208612021-11-27 The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran Khankeh, Hamid Reza Farrokhi, Mehrdad Khanjani, Mohammad Saeed Momtaz, Yadollah Abolfathi Forouzan, Ameneh Setareh Norouzi, Mehdi Ahmadi, Shokoufeh Harouni, Gholamreza Ghaedamini Roudini, Juliet Ghanaatpisheh, Elham Hamedanchi, Arya Pourebrahimi, Mohammad Alipour, Fardin Ranjbar, Maryam Naghikhani, Mehrdad Saatchi, Mohammad Vaccines (Basel) Article Acceptance and willingness to receive the vaccine are among the main factors in the success or failure of a health system in implementing the vaccination program. The present study was conducted in Tehran, the political and economic capital of Iran, to determine the acceptance of the COVID-19 vaccine and identify its associated factors, and explain the most important barriers and acceptance strategies for vaccination. This research was a concurrent quantitative and qualitative mixed-method study. In the quantitative part, 1200 individuals aged more than 18 years were selected from the households in 22 districts of Tehran City, with a multistage stratified cluster sampling method. Two questionnaires were used to evaluate the acceptance of the COVID-19 vaccine and vaccine acceptance determinants. The qualitative content analysis method addressed the influencing factors, as well as challenges and strategies related to the acceptance of the COVID-19 vaccine in four groups of Tehran inhabitants: the elderly, people with underlying diseases, healthcare workers, and the general population. The related data were simultaneously collected by applying in-depth semi-structural interviews and a data analysis process. Furthermore, we used the Graneheim and Lundman method for data analysis. We analyzed the data of 1200 people with a mean (SD) age of 46.4 (11.1) years, and approximately 58% of them were men. The vaccine acceptance was 83.6% (95% CI: 81.3–85.9). Among those who welcomed vaccination, 58% preferred the imported vaccines, 25% the Iranian ones, and 17% both. There was a significant association between the variables of age (adjusted odds ratio [AOR] = 1.72, 95% CI: 1.01–2.93), being single (AOR = 0.54, 95% CI: 0.41–0.91), moderate pharmacotherapy adherence (AOR = 0.58, 95% CI: 0.4–0.85), and the willingness to receive COVID-19 vaccine. Qualitative study after interviewing 45 people from four study groups showed an insufficient social trust in healthcare system officials, pharmaceutical and vaccine production companies; distrust in the effectiveness of the vaccines, concerns about the vaccine adverse effects, being tracked by microchips after vaccination, traditional anti-vaccination movements, the feeling the inessentiality of vaccination, and uncertainty about the fair distribution of the vaccine. These concerns were the main challenges addressed by the study groups. A good proportion of Tehran residents reported their willingness to receive the COVID-19 vaccine. Additionally, they expressed their critical concerns, such as insufficient trust in the healthcare system, vaccine safeties, and adverse effects that were the significant barriers to vaccine acceptance. It seems that conflicts raised by the shortage of vaccines and their import due to the sanctions have led to intense desire and demand in the general population, and especially the elderly, for vaccination. Besides, vaccination phobia in some individuals requires further investigations. MDPI 2021-10-28 /pmc/articles/PMC8620861/ /pubmed/34835179 http://dx.doi.org/10.3390/vaccines9111248 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khankeh, Hamid Reza
Farrokhi, Mehrdad
Khanjani, Mohammad Saeed
Momtaz, Yadollah Abolfathi
Forouzan, Ameneh Setareh
Norouzi, Mehdi
Ahmadi, Shokoufeh
Harouni, Gholamreza Ghaedamini
Roudini, Juliet
Ghanaatpisheh, Elham
Hamedanchi, Arya
Pourebrahimi, Mohammad
Alipour, Fardin
Ranjbar, Maryam
Naghikhani, Mehrdad
Saatchi, Mohammad
The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran
title The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran
title_full The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran
title_fullStr The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran
title_full_unstemmed The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran
title_short The Barriers, Challenges, and Strategies of COVID-19 (SARS-CoV-2) Vaccine Acceptance: A Concurrent Mixed-Method Study in Tehran City, Iran
title_sort barriers, challenges, and strategies of covid-19 (sars-cov-2) vaccine acceptance: a concurrent mixed-method study in tehran city, iran
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620861/
https://www.ncbi.nlm.nih.gov/pubmed/34835179
http://dx.doi.org/10.3390/vaccines9111248
work_keys_str_mv AT khankehhamidreza thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT farrokhimehrdad thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT khanjanimohammadsaeed thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT momtazyadollahabolfathi thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT forouzanamenehsetareh thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT norouzimehdi thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT ahmadishokoufeh thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT harounigholamrezaghaedamini thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT roudinijuliet thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT ghanaatpishehelham thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT hamedanchiarya thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT pourebrahimimohammad thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT alipourfardin thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT ranjbarmaryam thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT naghikhanimehrdad thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT saatchimohammad thebarrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT khankehhamidreza barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT farrokhimehrdad barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT khanjanimohammadsaeed barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT momtazyadollahabolfathi barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT forouzanamenehsetareh barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT norouzimehdi barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT ahmadishokoufeh barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT harounigholamrezaghaedamini barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT roudinijuliet barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT ghanaatpishehelham barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT hamedanchiarya barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT pourebrahimimohammad barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT alipourfardin barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT ranjbarmaryam barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT naghikhanimehrdad barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran
AT saatchimohammad barrierschallengesandstrategiesofcovid19sarscov2vaccineacceptanceaconcurrentmixedmethodstudyintehrancityiran