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Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome
Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620927/ https://www.ncbi.nlm.nih.gov/pubmed/34821705 http://dx.doi.org/10.3390/jcdd8110152 |
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author | Papadopoulos, Georgios E. Evaggelou, Theoxaris I. Moulias, Errikos K. Tsonis, Orestis Zekios, Konstantinos C. Nikas, Dimitrios N. Tzimas, Petros Paschopoulos, Minas Kolettis, Theofilos M. |
author_facet | Papadopoulos, Georgios E. Evaggelou, Theoxaris I. Moulias, Errikos K. Tsonis, Orestis Zekios, Konstantinos C. Nikas, Dimitrios N. Tzimas, Petros Paschopoulos, Minas Kolettis, Theofilos M. |
author_sort | Papadopoulos, Georgios E. |
collection | PubMed |
description | Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of delivery. Here, we explored the hypothesis that the different management of cesarean and vaginal delivery may elicit diverse responses affecting both autonomic arms. For this aim, continuous electrocardiographic recording was performed in 20 women during labor, and non-invasive indices of sympathetic and vagal activity were compared between the two modes of delivery. We report sympathetic prevalence during cesarean delivery, caused by marked vagal withdrawal, whereas autonomic activity was rather stable during vaginal delivery. These differences may be attributed to the effects of anesthesia during cesarean delivery, along with the protective effects of oxytocin administration during vaginal delivery. Our results provide further insights on autonomic responses during labor that may prove useful in the prevention of complications, such as takotsubo syndrome. |
format | Online Article Text |
id | pubmed-8620927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86209272021-11-27 Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome Papadopoulos, Georgios E. Evaggelou, Theoxaris I. Moulias, Errikos K. Tsonis, Orestis Zekios, Konstantinos C. Nikas, Dimitrios N. Tzimas, Petros Paschopoulos, Minas Kolettis, Theofilos M. J Cardiovasc Dev Dis Article Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of delivery. Here, we explored the hypothesis that the different management of cesarean and vaginal delivery may elicit diverse responses affecting both autonomic arms. For this aim, continuous electrocardiographic recording was performed in 20 women during labor, and non-invasive indices of sympathetic and vagal activity were compared between the two modes of delivery. We report sympathetic prevalence during cesarean delivery, caused by marked vagal withdrawal, whereas autonomic activity was rather stable during vaginal delivery. These differences may be attributed to the effects of anesthesia during cesarean delivery, along with the protective effects of oxytocin administration during vaginal delivery. Our results provide further insights on autonomic responses during labor that may prove useful in the prevention of complications, such as takotsubo syndrome. MDPI 2021-11-07 /pmc/articles/PMC8620927/ /pubmed/34821705 http://dx.doi.org/10.3390/jcdd8110152 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Papadopoulos, Georgios E. Evaggelou, Theoxaris I. Moulias, Errikos K. Tsonis, Orestis Zekios, Konstantinos C. Nikas, Dimitrios N. Tzimas, Petros Paschopoulos, Minas Kolettis, Theofilos M. Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome |
title | Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome |
title_full | Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome |
title_fullStr | Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome |
title_full_unstemmed | Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome |
title_short | Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome |
title_sort | autonomic responses during labor: potential implications for takotsubo syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620927/ https://www.ncbi.nlm.nih.gov/pubmed/34821705 http://dx.doi.org/10.3390/jcdd8110152 |
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