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Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults

Background: Lactose intolerance is the most frequent food intolerance, but many subjects with self-reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in SRMI patients and their clinical...

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Autores principales: Carroccio, Antonio, Soresi, Maurizio, Mantia, Beatrice, Fayer, Francesca, La Blasca, Francesco, Seidita, Aurelio, D’Alcamo, Alberto, Florena, Ada Maria, Tinè, Chiara, Garlisi, Chiara, Mansueto, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621065/
https://www.ncbi.nlm.nih.gov/pubmed/34836089
http://dx.doi.org/10.3390/nu13113833
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author Carroccio, Antonio
Soresi, Maurizio
Mantia, Beatrice
Fayer, Francesca
La Blasca, Francesco
Seidita, Aurelio
D’Alcamo, Alberto
Florena, Ada Maria
Tinè, Chiara
Garlisi, Chiara
Mansueto, Pasquale
author_facet Carroccio, Antonio
Soresi, Maurizio
Mantia, Beatrice
Fayer, Francesca
La Blasca, Francesco
Seidita, Aurelio
D’Alcamo, Alberto
Florena, Ada Maria
Tinè, Chiara
Garlisi, Chiara
Mansueto, Pasquale
author_sort Carroccio, Antonio
collection PubMed
description Background: Lactose intolerance is the most frequent food intolerance, but many subjects with self-reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in SRMI patients and their clinical characteristics. Methods: In a retrospective study, the clinical records of 314 SRMI patients (259 females, mean age: 39.1 ± 13.5 years) were reviewed; 102 patients with irritable bowel syndrome (IBS) served as controls. In a prospective study, 42 SRMI patients, negatives at the LHBT, underwent a double-blind, placebo-controlled (DBPC) whole cow’s milk challenge. Results: In the retrospective study, only 178 patients (56%) were lactose maldigesters and intolerant at LHBT; 68% of the subjects with SRMI were suffering from IBS; 74% reported dyspepsia (p = 0.0001 vs. IBS controls); and weight loss was recorded in 62 SRMI patients (20%) (p = 0.01 vs. IBS controls). Duodenal histology showed intra-epithelial lymphocytosis in about 60% of cases. In the prospective study, 36 patients (86%) experienced symptoms during the DBPC cow’s milk challenge, and only 4 patients (9%) reacted to placebo (p = 0.0001). Conclusions: A percentage of SRMI patients were not suffering from lactose intolerance. DBPC revealed that SRMI patients had clinical reactions when exposed to whole cow’s milk.
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spelling pubmed-86210652021-11-27 Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults Carroccio, Antonio Soresi, Maurizio Mantia, Beatrice Fayer, Francesca La Blasca, Francesco Seidita, Aurelio D’Alcamo, Alberto Florena, Ada Maria Tinè, Chiara Garlisi, Chiara Mansueto, Pasquale Nutrients Article Background: Lactose intolerance is the most frequent food intolerance, but many subjects with self-reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in SRMI patients and their clinical characteristics. Methods: In a retrospective study, the clinical records of 314 SRMI patients (259 females, mean age: 39.1 ± 13.5 years) were reviewed; 102 patients with irritable bowel syndrome (IBS) served as controls. In a prospective study, 42 SRMI patients, negatives at the LHBT, underwent a double-blind, placebo-controlled (DBPC) whole cow’s milk challenge. Results: In the retrospective study, only 178 patients (56%) were lactose maldigesters and intolerant at LHBT; 68% of the subjects with SRMI were suffering from IBS; 74% reported dyspepsia (p = 0.0001 vs. IBS controls); and weight loss was recorded in 62 SRMI patients (20%) (p = 0.01 vs. IBS controls). Duodenal histology showed intra-epithelial lymphocytosis in about 60% of cases. In the prospective study, 36 patients (86%) experienced symptoms during the DBPC cow’s milk challenge, and only 4 patients (9%) reacted to placebo (p = 0.0001). Conclusions: A percentage of SRMI patients were not suffering from lactose intolerance. DBPC revealed that SRMI patients had clinical reactions when exposed to whole cow’s milk. MDPI 2021-10-27 /pmc/articles/PMC8621065/ /pubmed/34836089 http://dx.doi.org/10.3390/nu13113833 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carroccio, Antonio
Soresi, Maurizio
Mantia, Beatrice
Fayer, Francesca
La Blasca, Francesco
Seidita, Aurelio
D’Alcamo, Alberto
Florena, Ada Maria
Tinè, Chiara
Garlisi, Chiara
Mansueto, Pasquale
Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults
title Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults
title_full Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults
title_fullStr Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults
title_full_unstemmed Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults
title_short Whole Cow’s Milk but Not Lactose Can Induce Symptoms in Patients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults
title_sort whole cow’s milk but not lactose can induce symptoms in patients with self-reported milk intolerance: evidence of cow’s milk sensitivity in adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621065/
https://www.ncbi.nlm.nih.gov/pubmed/34836089
http://dx.doi.org/10.3390/nu13113833
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