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The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective

The immune system contributes to maintaining the body’s functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debr...

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Autores principales: Ernst, Lena M., Casals, Eudald, Italiani, Paola, Boraschi, Diana, Puntes, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621168/
https://www.ncbi.nlm.nih.gov/pubmed/34835755
http://dx.doi.org/10.3390/nano11112991
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author Ernst, Lena M.
Casals, Eudald
Italiani, Paola
Boraschi, Diana
Puntes, Victor
author_facet Ernst, Lena M.
Casals, Eudald
Italiani, Paola
Boraschi, Diana
Puntes, Victor
author_sort Ernst, Lena M.
collection PubMed
description The immune system contributes to maintaining the body’s functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debris or misfolded/degraded proteins). Accordingly, the immune system can detect molecular and cellular structures with a spatial resolution of a few nm, which allows for detecting molecular patterns expressed in a great variety of pathogens, including viral and bacterial proteins and bacterial nucleic acid sequences. Such patterns are also expressed in abnormal cells. In this context, it is expected that nanostructured materials in the size range of proteins, protein aggregates, and viruses with different molecular coatings can engage in a sophisticated interaction with the immune system. Nanoparticles can be recognized or passed undetected by the immune system. Once detected, they can be tolerated or induce defensive (inflammatory) or anti-inflammatory responses. This paper describes the different modes of interaction between nanoparticles, especially inorganic nanoparticles, and the immune system, especially the innate immune system. This perspective should help to propose a set of selection rules for nanosafety-by-design and medical nanoparticle design.
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spelling pubmed-86211682021-11-27 The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective Ernst, Lena M. Casals, Eudald Italiani, Paola Boraschi, Diana Puntes, Victor Nanomaterials (Basel) Review The immune system contributes to maintaining the body’s functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debris or misfolded/degraded proteins). Accordingly, the immune system can detect molecular and cellular structures with a spatial resolution of a few nm, which allows for detecting molecular patterns expressed in a great variety of pathogens, including viral and bacterial proteins and bacterial nucleic acid sequences. Such patterns are also expressed in abnormal cells. In this context, it is expected that nanostructured materials in the size range of proteins, protein aggregates, and viruses with different molecular coatings can engage in a sophisticated interaction with the immune system. Nanoparticles can be recognized or passed undetected by the immune system. Once detected, they can be tolerated or induce defensive (inflammatory) or anti-inflammatory responses. This paper describes the different modes of interaction between nanoparticles, especially inorganic nanoparticles, and the immune system, especially the innate immune system. This perspective should help to propose a set of selection rules for nanosafety-by-design and medical nanoparticle design. MDPI 2021-11-06 /pmc/articles/PMC8621168/ /pubmed/34835755 http://dx.doi.org/10.3390/nano11112991 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ernst, Lena M.
Casals, Eudald
Italiani, Paola
Boraschi, Diana
Puntes, Victor
The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective
title The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective
title_full The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective
title_fullStr The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective
title_full_unstemmed The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective
title_short The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective
title_sort interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621168/
https://www.ncbi.nlm.nih.gov/pubmed/34835755
http://dx.doi.org/10.3390/nano11112991
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