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Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies
The COVID-19 pandemic has had an enormous impact on economies and health systems globally, therefore a top priority is the development of increasingly better diagnostic and surveillance alternatives to slow down the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In order...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621220/ https://www.ncbi.nlm.nih.gov/pubmed/34829328 http://dx.doi.org/10.3390/diagnostics11111981 |
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author | Guaman-Bautista, Linda P. Moreta-Urbano, Erick Oña-Arias, Claudia G. Torres-Arias, Marbel Kyriakidis, Nikolaos C. Malcı, Koray Jonguitud-Borrego, Nestor Rios-Solis, Leonardo Ramos-Martinez, Espiridion López-Cortés, Andrés Barba-Ostria, Carlos |
author_facet | Guaman-Bautista, Linda P. Moreta-Urbano, Erick Oña-Arias, Claudia G. Torres-Arias, Marbel Kyriakidis, Nikolaos C. Malcı, Koray Jonguitud-Borrego, Nestor Rios-Solis, Leonardo Ramos-Martinez, Espiridion López-Cortés, Andrés Barba-Ostria, Carlos |
author_sort | Guaman-Bautista, Linda P. |
collection | PubMed |
description | The COVID-19 pandemic has had an enormous impact on economies and health systems globally, therefore a top priority is the development of increasingly better diagnostic and surveillance alternatives to slow down the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In order to establish massive testing and contact tracing policies, it is crucial to have a clear view of the diagnostic options available and their principal advantages and drawbacks. Although classical molecular methods such as RT-qPCR are broadly used, diagnostic alternatives based on technologies such as LAMP, antigen, serological testing, or the application of novel technologies such as CRISPR-Cas for diagnostics, are also discussed. The present review also discusses the most important automation strategies employed to increase testing capability. Several serological-based diagnostic kits are presented, as well as novel nanotechnology-based diagnostic methods. In summary, this review provides a clear diagnostic landscape of the most relevant tools to track COVID-19. |
format | Online Article Text |
id | pubmed-8621220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86212202021-11-27 Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies Guaman-Bautista, Linda P. Moreta-Urbano, Erick Oña-Arias, Claudia G. Torres-Arias, Marbel Kyriakidis, Nikolaos C. Malcı, Koray Jonguitud-Borrego, Nestor Rios-Solis, Leonardo Ramos-Martinez, Espiridion López-Cortés, Andrés Barba-Ostria, Carlos Diagnostics (Basel) Review The COVID-19 pandemic has had an enormous impact on economies and health systems globally, therefore a top priority is the development of increasingly better diagnostic and surveillance alternatives to slow down the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In order to establish massive testing and contact tracing policies, it is crucial to have a clear view of the diagnostic options available and their principal advantages and drawbacks. Although classical molecular methods such as RT-qPCR are broadly used, diagnostic alternatives based on technologies such as LAMP, antigen, serological testing, or the application of novel technologies such as CRISPR-Cas for diagnostics, are also discussed. The present review also discusses the most important automation strategies employed to increase testing capability. Several serological-based diagnostic kits are presented, as well as novel nanotechnology-based diagnostic methods. In summary, this review provides a clear diagnostic landscape of the most relevant tools to track COVID-19. MDPI 2021-10-26 /pmc/articles/PMC8621220/ /pubmed/34829328 http://dx.doi.org/10.3390/diagnostics11111981 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guaman-Bautista, Linda P. Moreta-Urbano, Erick Oña-Arias, Claudia G. Torres-Arias, Marbel Kyriakidis, Nikolaos C. Malcı, Koray Jonguitud-Borrego, Nestor Rios-Solis, Leonardo Ramos-Martinez, Espiridion López-Cortés, Andrés Barba-Ostria, Carlos Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies |
title | Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies |
title_full | Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies |
title_fullStr | Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies |
title_full_unstemmed | Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies |
title_short | Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies |
title_sort | tracking sars-cov-2: novel trends and diagnostic strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621220/ https://www.ncbi.nlm.nih.gov/pubmed/34829328 http://dx.doi.org/10.3390/diagnostics11111981 |
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