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Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions

The novel coronavirus disease (COVID-19), the reason for worldwide pandemic, has already masked around 220 countries globally. This disease is induced by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Arising environmental stress, increase in the oxidative stress level, weak immunity...

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Autores principales: Saha, Priyanka, Bose, Subhankar, Srivastava, Amit Kumar, Chaudhary, Anis Ahmad, Lall, Rajiv, Prasad, Sahdeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621307/
https://www.ncbi.nlm.nih.gov/pubmed/34833873
http://dx.doi.org/10.3390/molecules26226783
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author Saha, Priyanka
Bose, Subhankar
Srivastava, Amit Kumar
Chaudhary, Anis Ahmad
Lall, Rajiv
Prasad, Sahdeo
author_facet Saha, Priyanka
Bose, Subhankar
Srivastava, Amit Kumar
Chaudhary, Anis Ahmad
Lall, Rajiv
Prasad, Sahdeo
author_sort Saha, Priyanka
collection PubMed
description The novel coronavirus disease (COVID-19), the reason for worldwide pandemic, has already masked around 220 countries globally. This disease is induced by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Arising environmental stress, increase in the oxidative stress level, weak immunity and lack of nutrition deteriorates the clinical status of the infected patients. Though several researches are at its peak for understanding and bringing forward effective therapeutics, yet there is no promising solution treating this disease directly. Medicinal plants and their active metabolites have always been promising in treating many clinical complications since time immemorial. Mother nature provides vivid chemical structures, which act multi-dimensionally all alone or synergistically in mitigating several diseases. Their unique antioxidant and anti-inflammatory activity with least side effects have made them more effective candidate for pharmacological studies. These medicinal plants inhibit attachment, encapsulation and replication of COVID-19 viruses by targeting various signaling molecules such as angiotensin converting enzyme-2, transmembrane serine protease 2, spike glycoprotein, main protease etc. This property is re-examined and its potency is now used to improve the existing global health crisis. This review is an attempt to focus various antiviral activities of various noteworthy medicinal plants. Moreover, its implications as prophylactic or preventive in various secondary complications including neurological, cardiovascular, acute kidney disease, liver disease are also pinpointed in the present review. This knowledge will help emphasis on the therapeutic developments for this novel coronavirus where it can be used as alone or in combination with the repositioned drugs to combat COVID-19.
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spelling pubmed-86213072021-11-27 Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions Saha, Priyanka Bose, Subhankar Srivastava, Amit Kumar Chaudhary, Anis Ahmad Lall, Rajiv Prasad, Sahdeo Molecules Review The novel coronavirus disease (COVID-19), the reason for worldwide pandemic, has already masked around 220 countries globally. This disease is induced by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Arising environmental stress, increase in the oxidative stress level, weak immunity and lack of nutrition deteriorates the clinical status of the infected patients. Though several researches are at its peak for understanding and bringing forward effective therapeutics, yet there is no promising solution treating this disease directly. Medicinal plants and their active metabolites have always been promising in treating many clinical complications since time immemorial. Mother nature provides vivid chemical structures, which act multi-dimensionally all alone or synergistically in mitigating several diseases. Their unique antioxidant and anti-inflammatory activity with least side effects have made them more effective candidate for pharmacological studies. These medicinal plants inhibit attachment, encapsulation and replication of COVID-19 viruses by targeting various signaling molecules such as angiotensin converting enzyme-2, transmembrane serine protease 2, spike glycoprotein, main protease etc. This property is re-examined and its potency is now used to improve the existing global health crisis. This review is an attempt to focus various antiviral activities of various noteworthy medicinal plants. Moreover, its implications as prophylactic or preventive in various secondary complications including neurological, cardiovascular, acute kidney disease, liver disease are also pinpointed in the present review. This knowledge will help emphasis on the therapeutic developments for this novel coronavirus where it can be used as alone or in combination with the repositioned drugs to combat COVID-19. MDPI 2021-11-10 /pmc/articles/PMC8621307/ /pubmed/34833873 http://dx.doi.org/10.3390/molecules26226783 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saha, Priyanka
Bose, Subhankar
Srivastava, Amit Kumar
Chaudhary, Anis Ahmad
Lall, Rajiv
Prasad, Sahdeo
Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions
title Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions
title_full Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions
title_fullStr Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions
title_full_unstemmed Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions
title_short Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions
title_sort jeopardy of covid-19: rechecking the perks of phytotherapeutic interventions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621307/
https://www.ncbi.nlm.nih.gov/pubmed/34833873
http://dx.doi.org/10.3390/molecules26226783
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