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Biomarkers Utility: At the Borderline between Cardiology and Neurology

Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being im...

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Autores principales: Ion, Adriana, Stafie, Celina, Mitu, Ovidiu, Ciobanu, Cosmina Elena, Halitchi, Dan Iliescu, Costache, Alexandru Dan, Bobric, Cezara, Troase, Roxana, Mitu, Ivona, Huzum, Bogdan, Duca, Stefania Teodora, Costache, Irina Iuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621331/
https://www.ncbi.nlm.nih.gov/pubmed/34821692
http://dx.doi.org/10.3390/jcdd8110139
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author Ion, Adriana
Stafie, Celina
Mitu, Ovidiu
Ciobanu, Cosmina Elena
Halitchi, Dan Iliescu
Costache, Alexandru Dan
Bobric, Cezara
Troase, Roxana
Mitu, Ivona
Huzum, Bogdan
Duca, Stefania Teodora
Costache, Irina Iuliana
author_facet Ion, Adriana
Stafie, Celina
Mitu, Ovidiu
Ciobanu, Cosmina Elena
Halitchi, Dan Iliescu
Costache, Alexandru Dan
Bobric, Cezara
Troase, Roxana
Mitu, Ivona
Huzum, Bogdan
Duca, Stefania Teodora
Costache, Irina Iuliana
author_sort Ion, Adriana
collection PubMed
description Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being implemented. Cardiovascular and neurological diseases often share common risk factors and pathological pathways which may play an important role in the use and interpretation of biomarkers’ values. Among the biomarkers used extensively in clinical practice in cardiology, hs-TroponinT, CK-MB and NTproBNP have been shown to be strongly influenced by multiple neurological conditions. Newer ones such as galectin-3, lysophosphatidylcholine, copeptin, sST2, S100B, myeloperoxidase and GDF-15 have been extensively studied in recent years as alternatives with an increased sensitivity for cardiovascular diseases, but also with significant results in the field of neurology. Thus, given their low specificity, the values interpretation must be correlated with the clinical judgment and other available investigations.
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spelling pubmed-86213312021-11-27 Biomarkers Utility: At the Borderline between Cardiology and Neurology Ion, Adriana Stafie, Celina Mitu, Ovidiu Ciobanu, Cosmina Elena Halitchi, Dan Iliescu Costache, Alexandru Dan Bobric, Cezara Troase, Roxana Mitu, Ivona Huzum, Bogdan Duca, Stefania Teodora Costache, Irina Iuliana J Cardiovasc Dev Dis Review Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being implemented. Cardiovascular and neurological diseases often share common risk factors and pathological pathways which may play an important role in the use and interpretation of biomarkers’ values. Among the biomarkers used extensively in clinical practice in cardiology, hs-TroponinT, CK-MB and NTproBNP have been shown to be strongly influenced by multiple neurological conditions. Newer ones such as galectin-3, lysophosphatidylcholine, copeptin, sST2, S100B, myeloperoxidase and GDF-15 have been extensively studied in recent years as alternatives with an increased sensitivity for cardiovascular diseases, but also with significant results in the field of neurology. Thus, given their low specificity, the values interpretation must be correlated with the clinical judgment and other available investigations. MDPI 2021-10-25 /pmc/articles/PMC8621331/ /pubmed/34821692 http://dx.doi.org/10.3390/jcdd8110139 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ion, Adriana
Stafie, Celina
Mitu, Ovidiu
Ciobanu, Cosmina Elena
Halitchi, Dan Iliescu
Costache, Alexandru Dan
Bobric, Cezara
Troase, Roxana
Mitu, Ivona
Huzum, Bogdan
Duca, Stefania Teodora
Costache, Irina Iuliana
Biomarkers Utility: At the Borderline between Cardiology and Neurology
title Biomarkers Utility: At the Borderline between Cardiology and Neurology
title_full Biomarkers Utility: At the Borderline between Cardiology and Neurology
title_fullStr Biomarkers Utility: At the Borderline between Cardiology and Neurology
title_full_unstemmed Biomarkers Utility: At the Borderline between Cardiology and Neurology
title_short Biomarkers Utility: At the Borderline between Cardiology and Neurology
title_sort biomarkers utility: at the borderline between cardiology and neurology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621331/
https://www.ncbi.nlm.nih.gov/pubmed/34821692
http://dx.doi.org/10.3390/jcdd8110139
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