Cargando…
Biomarkers Utility: At the Borderline between Cardiology and Neurology
Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being im...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621331/ https://www.ncbi.nlm.nih.gov/pubmed/34821692 http://dx.doi.org/10.3390/jcdd8110139 |
_version_ | 1784605432052973568 |
---|---|
author | Ion, Adriana Stafie, Celina Mitu, Ovidiu Ciobanu, Cosmina Elena Halitchi, Dan Iliescu Costache, Alexandru Dan Bobric, Cezara Troase, Roxana Mitu, Ivona Huzum, Bogdan Duca, Stefania Teodora Costache, Irina Iuliana |
author_facet | Ion, Adriana Stafie, Celina Mitu, Ovidiu Ciobanu, Cosmina Elena Halitchi, Dan Iliescu Costache, Alexandru Dan Bobric, Cezara Troase, Roxana Mitu, Ivona Huzum, Bogdan Duca, Stefania Teodora Costache, Irina Iuliana |
author_sort | Ion, Adriana |
collection | PubMed |
description | Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being implemented. Cardiovascular and neurological diseases often share common risk factors and pathological pathways which may play an important role in the use and interpretation of biomarkers’ values. Among the biomarkers used extensively in clinical practice in cardiology, hs-TroponinT, CK-MB and NTproBNP have been shown to be strongly influenced by multiple neurological conditions. Newer ones such as galectin-3, lysophosphatidylcholine, copeptin, sST2, S100B, myeloperoxidase and GDF-15 have been extensively studied in recent years as alternatives with an increased sensitivity for cardiovascular diseases, but also with significant results in the field of neurology. Thus, given their low specificity, the values interpretation must be correlated with the clinical judgment and other available investigations. |
format | Online Article Text |
id | pubmed-8621331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86213312021-11-27 Biomarkers Utility: At the Borderline between Cardiology and Neurology Ion, Adriana Stafie, Celina Mitu, Ovidiu Ciobanu, Cosmina Elena Halitchi, Dan Iliescu Costache, Alexandru Dan Bobric, Cezara Troase, Roxana Mitu, Ivona Huzum, Bogdan Duca, Stefania Teodora Costache, Irina Iuliana J Cardiovasc Dev Dis Review Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being implemented. Cardiovascular and neurological diseases often share common risk factors and pathological pathways which may play an important role in the use and interpretation of biomarkers’ values. Among the biomarkers used extensively in clinical practice in cardiology, hs-TroponinT, CK-MB and NTproBNP have been shown to be strongly influenced by multiple neurological conditions. Newer ones such as galectin-3, lysophosphatidylcholine, copeptin, sST2, S100B, myeloperoxidase and GDF-15 have been extensively studied in recent years as alternatives with an increased sensitivity for cardiovascular diseases, but also with significant results in the field of neurology. Thus, given their low specificity, the values interpretation must be correlated with the clinical judgment and other available investigations. MDPI 2021-10-25 /pmc/articles/PMC8621331/ /pubmed/34821692 http://dx.doi.org/10.3390/jcdd8110139 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ion, Adriana Stafie, Celina Mitu, Ovidiu Ciobanu, Cosmina Elena Halitchi, Dan Iliescu Costache, Alexandru Dan Bobric, Cezara Troase, Roxana Mitu, Ivona Huzum, Bogdan Duca, Stefania Teodora Costache, Irina Iuliana Biomarkers Utility: At the Borderline between Cardiology and Neurology |
title | Biomarkers Utility: At the Borderline between Cardiology and Neurology |
title_full | Biomarkers Utility: At the Borderline between Cardiology and Neurology |
title_fullStr | Biomarkers Utility: At the Borderline between Cardiology and Neurology |
title_full_unstemmed | Biomarkers Utility: At the Borderline between Cardiology and Neurology |
title_short | Biomarkers Utility: At the Borderline between Cardiology and Neurology |
title_sort | biomarkers utility: at the borderline between cardiology and neurology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621331/ https://www.ncbi.nlm.nih.gov/pubmed/34821692 http://dx.doi.org/10.3390/jcdd8110139 |
work_keys_str_mv | AT ionadriana biomarkersutilityattheborderlinebetweencardiologyandneurology AT stafiecelina biomarkersutilityattheborderlinebetweencardiologyandneurology AT mituovidiu biomarkersutilityattheborderlinebetweencardiologyandneurology AT ciobanucosminaelena biomarkersutilityattheborderlinebetweencardiologyandneurology AT halitchidaniliescu biomarkersutilityattheborderlinebetweencardiologyandneurology AT costachealexandrudan biomarkersutilityattheborderlinebetweencardiologyandneurology AT bobriccezara biomarkersutilityattheborderlinebetweencardiologyandneurology AT troaseroxana biomarkersutilityattheborderlinebetweencardiologyandneurology AT mituivona biomarkersutilityattheborderlinebetweencardiologyandneurology AT huzumbogdan biomarkersutilityattheborderlinebetweencardiologyandneurology AT ducastefaniateodora biomarkersutilityattheborderlinebetweencardiologyandneurology AT costacheirinaiuliana biomarkersutilityattheborderlinebetweencardiologyandneurology |